A Case Study of Nivolumab for Relapsed/Refractory Primary Central Nervous System Lymphoma
- Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Study ID
- NCT04845139
- Status
- Unknown
Conditions
- Primary Central Nervous System Lymphoma
- Refractory Central Nervous System Lymphoma
- Relapsed Primary Central Nervous System Lymphoma
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - 80 Years
- Healthy Volunteers
- Not accepted
Interventions
- Nivolumab — DRUGNivolumab given intraventricularly
Study Details
The purpose of this study is to determine whether Nivolumab given intrathecally is effective in the treatment of Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)
Key Dates
- Start date
- Jul 2, 2022
- Status verified
- Jul 2022
- Primary completion
- Oct 30, 2022
- Completion
- Nov 30, 2022
Study Design
- Enrollment
- 1 participants (actual)
- Allocation
- NA
- Intervention model
- SINGLE_GROUP
- Primary purpose
- TREATMENT
Arms
- Experimental: Nivolumab administrationNivolumab administration Q2W by intraventricular injection through Ommaya reservoir
Primary Outcome Measure
Adverse events [ Time Frame: On a continuous basis up to 1 month after the first dose of study drug ]
Related Studies
- CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)PHASE1/PHASE2 · Recruiting · Curis, Inc. · Phoenix, Arizona
- Pembrolizumab, Ibrutinib and Rituximab in PCNSLPHASE1/PHASE2 · Recruiting · Dana-Farber Cancer Institute · Boston, Massachusetts
- Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSLPHASE2 · Recruiting · Lakshmi Nayak, MD · Boston, Massachusetts
- Tafasitamab Plus Lenalidomide in Relapsed CNS LymphomaPHASE1/PHASE2 · Recruiting · James Rubenstein · San Francisco, California