Effects of Empagliflozin in Reducing Oxidative Stress After Kidney Transplantation

Sponsor
Shahid Beheshti University of Medical Sciences
Study ID
NCT04918407
Status
Completed

Conditions

  • Kidney Transplant; Complications

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to investigate the effect of empagliflozin on oxidative stress in patients with type 2 diabetes after kidney transplantation. The association is examined by comparing the difference in oxidative modifications before and after 90 days treatment with 25 mg empagliflozin plus insulin compared to insulin treatment. The study is randomised and double-blinded. Each treatment group consists of 20 patients. Oxidative stress markers are measured by serum level of superoxide dismutase activity ,lipid peroxidation assay kit, glutathione assay, glutathione peroxidase activity , total antioxidant capacity assay oxidant status , carbonyl content assay and bca protein assay . . A student t-test will be performed to compare adding empagliflozin . The results will be published in a peer-review journal.

Key Dates

Start date
Jan 1, 2022
Status verified
Sep 2025
Primary completion
Jul 5, 2025
Completion
Aug 5, 2025

Study Design

Enrollment
40 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Empagliflozin
    Adding 25mg Empagliflozin on Insulin
  • Active Comparator: Insulin alone
    Just contriling the blood glucose with Insulin

Primary Outcome Measure

serum level of superoxide dismutase [ Time Frame: Change from baseline after 90 days of intervention ]

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