Assessment of the Functional Outcome and Quality of Life in Sarcoma Patients

Sponsor
Universitaire Ziekenhuizen KU Leuven
Study ID
NCT05051059
Status
Recruiting
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Conditions

  • Bone Sarcoma
  • Soft Tissue Sarcoma

Eligibility Criteria

Sex
ALL
Age
18 Years - 95 Years
Healthy Volunteers
Accepted

Interventions

  • Functional outcome — OTHER
    3D-motion analysis and strength assessment
  • Health related quality of life (HRQoL) assessment — OTHER
    Quality of Life Questionnaire C-30 (QLQ-C30), Impact on Participation and Autonomy Questionnaire (IPAQ) and Musculoskeletal Tumor Society Score (MSTS)

Study Details

Primary bone and soft tissue sarcomas are an exceptionally rare form of cancer, collectively accounting for only 1% of all malignancies diagnosed. Sarcomas often occur in the patients' extremities and treatment typically involves limb salvage surgery with bone and/or muscle resection. These surgeries often leave the patients with disfigurements, psychological trauma, and functional disabilities. Perhaps, the most difficult and life-altering decision that patients (and their parents) with primary bone sarcomas about the knee joint have to make, involves choosing the type of surgical procedure that will provide them with the outcome that meets their functional as well as aesthetic expectations. In literature, the quality of life for patients with osteosarcoma around the knee joint after three different surgical procedures, that is, amputation, endoprosthetic reconstruction and rotationplasty was evaluated. There was found that patients treated with rotationplasty showed significantly higher functional scores compared to the two other groups of patients. Also, researchers investigated the long-term quality of life after bone sarcoma surgery around the knee joint and found that, despite the functional disability, survivors were busy with work, study, relationships, and sometimes they have founded a family. Most published reports in the literature on assessment of gait in the lower-extremity sarcoma survivors were focused on bone sarcoma patients after wide resection and endoprosthetic reconstruction. To the knowledge of the investigator, there has been no published studies on gait analysis after resection of soft tissue sarcomas (STS) of the lower extremity. The rare and heterogeneous aspects of STS and the paucity of knowledge of movement strategies in these patients hinder the development of effective rehabilitation protocols for recovering movement after resection of STS in the lower limb.

Key Dates

First listed
Sep 21, 2021
Start date
Oct 1, 2021
Status verified
Mar 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Other: Soft tissue sarcoma of the thigh
    Patients who underwent surgical resection of a deep intramuscular soft tissue sarcoma of the thigh
  • No Intervention: Control group
    A group of healthy age-matched individuals will be identified out of an available gait lab database to compare the gait pattern with tha of the patient group
  • Other: Bone or soft tissue sarcoma of the lower extremity
    Patients who underwent surgical resection of a bone or soft tissue sarcoma of the lower extremity

Primary Outcome Measure

Musculoskeletal Tumor Society Score (MSTS) [ Time Frame: Within a period of 1 year ]

Central Contacts

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