Evaluation of Oral THC and CBD in Men and Women

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT05067387
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Drug Abuse
  • Impairment
  • Intoxication by Drug

Eligibility Criteria

Sex
ALL
Age
21 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Placebo — DRUG
    Oral placebo
  • THC — DRUG
    Oral THC (20 mg)
  • CBD — DRUG
    Oral CBD (20 mg)
  • THC + CBD — DRUG
    Oral THC (20 mg) + CBD (20 mg)

Study Details

The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of oral delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) and to evaluate detection of recently smoked THC in oral fluid.

Key Dates

First listed
Oct 5, 2021
Start date
Aug 13, 2026
Status verified
Sep 2026
Primary completion
Jun 15, 2027
Completion
Jun 15, 2028

Study Design

Enrollment
22 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Placebo
    Oral placebo; sesame and MCT oil
  • Experimental: 20 mg THC
    THC suspended in sesame oil
  • Experimental: 20 mg CBD
    CBD suspended in MCT oil
  • Experimental: 20 mg THC + 20 mg CBD
    THC and CBD in sesame and MCT oil

Primary Outcome Measure

Ratings of subjective drug effects [ Time Frame: 6 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, Los AngelesLos AngelesCalifornia90095
Ziva Cooper, PhD
[email protected]
310-206-9942
Vince Acebo
[email protected]
310-983-3417

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By research site
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