A Study of Repotrectinib in Combination With Other Anticancer Therapies for the Treatment of Subjects With KRAS-Mutant Solid Tumors

Part of paid clinical trials in California City, California.

Sponsor
Turning Point Therapeutics, Inc.
Study ID
NCT05071183
Phase
PHASE1/PHASE2
Status
Terminated

Conditions

  • Advanced Solid Tumor
  • KRAS Mutation-Related Tumors
  • Metastatic Solid Tumor

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • TPX-0005 — DRUG
    Oral TPX-0005 capsules
  • Trametinib — DRUG
    Oral trametinib tablets

Study Details

A Phase 1b/2 Study of Repotrectinib in Combination with Other Anticancer Therapies for the Treatment of Subjects with KRAS-Mutant Advanced Solid Tumors (TRIDENT-2)

Key Dates

Start date
Sep 23, 2021
Status verified
Mar 2024
Primary completion
Mar 1, 2023
Completion
Mar 1, 2023

Study Design

Enrollment
9 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: TPX-0005 + Trametinib
    TPX-0005 + Trametinib Dose Escalation and Dose Expansion Dose escalation: KRAS G12D mutant advanced solid tumors. Dose expansion: KRAS G12D locally advanced or metastatic NSCLC

Primary Outcome Measure

Number of Participants With Dose Limiting Toxicities [ Time Frame: From initial dose to end of first cycle of treatment, approximately 28 days ]

Locations (6)

FacilityCityStateZIPSite coordinators
Local Institution - 2101California CityCalifornia90033-
Local Institution - 2109California CityCalifornia92663-
Local Institution - 2106DenverColorado80218-
Local Institution - 2108NashvilleTennessee37203-
Local Institution - 2107HoustonTexas77030-
Local Institution - 2102Virginia BeachVirginia22031-

Find similar trials in California City, CA

By research site
Local Institution - 2101· California City, CALocal Institution - 2109· California City, CALocal Institution - 2106· Denver, COLocal Institution - 2108· Nashville, TNLocal Institution - 2107· Houston, TXLocal Institution - 2102· Virginia Beach, VA

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