The Oxford Risk Factors And Non-Invasive Imaging Study

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
University of Oxford
Study ID
NCT05169333
Status
Recruiting
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Conditions

  • Cardiovascular Diseases
  • Cardiovascular Risk Factors

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Study Details

ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.

Key Dates

First listed
Dec 23, 2021
Start date
Feb 23, 2016
Status verified
Dec 2024
Primary completion
Feb 28, 2030
Completion
Feb 28, 2030

Study Design

Enrollment
250,000 participants (estimated)

Arms

  • Arm: Group 1
    Participants attending cardiology department, hypertension or outpatient clinics.
  • Arm: Group 2
    Participants who are recruited prospectively, during their clinically indicated CT scan, and they are followed-up prospectively for clinical endpoints; A follow-up CCTA at least 6 months later will be offered to a subgroup of these patients, to assess disease progression.
  • Arm: Group 3
    Individuals where at least 6 months have elapsed from previous CCTA will undergo repeat CCTA scan and enter prospective follow up for clinical endpoints.
  • Arm: Group 4
    Cohort of consecutive patients who have undergone clinical CTAs or unenhanced CT chest, abdomen and pelvis in the past, linking the index CT scan with prospective outcomes collection already accumulated.

Primary Outcome Measure

Cardiac and all cause mortality [ Time Frame: 15 years ]

Central Contacts

Locations (12)

FacilityCityStateZIPSite coordinators
Valleywise HealthPhoenixArizona-
Nordstrom, Dr
[email protected]
Yale University, School of MedicineNew HavenConnecticut-
Evangelos, Dr
[email protected]
Bridging Medical SilosTampaFlorida-
Emory UniversityAtlantaGeorgia-
De Cecco, Prof
[email protected]
Midwest Heart & Vascular Specialists LLCKansas CityKansas-
St Luke's HospitalKansas CityKansas-
NIH National Heart, Lunch, and Blood InstituteBethesdaMaryland-
Brigham and Women's HospitalBostonMassachusetts-
Blankstein, Prof
[email protected]
Cleveland ClinicClevelandOhio-
UT Southwestern Medical CenterDallasTexas-
Brooke Army Medical Center (BAMC)San AntonioTexas-
Gore, Dr
University of VirginiaCharlottesvilleVirginia-
Villines, Prof
[email protected]

Find similar trials in Phoenix, AZ

By research site
Valleywise Health· Phoenix, AZYale University, School of Medicine· New Haven, CTBridging Medical Silos· Tampa, FLEmory University· Atlanta, GAMidwest Heart & Vascular Specialists LLC· Kansas City, KSSt Luke's Hospital· Kansas City, KS

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