Study of Novel Regimens in Relapsed or Refractory Multiple Myeloma

Part of paid clinical trials in Gilbert, Arizona.

Sponsor
iTeos Therapeutics
Study ID
NCT05289492
Phase
PHASE1
Status
Terminated

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • EOS884448 — DRUG
    EOS884448 will be administered in arm A,B and C
  • Iberdomide — DRUG
    Iberdomide will be administered in arm B and C
  • Dexamethasone — DRUG
    Dexamethasone will be administered in arm C

Study Details

This is a multicenter, open-label, phase I/II clinical study, to assess the safety, tolerability, antitumor activity, pharmacokinetics and pharmacodynamics of EOS884448 (also known as EOS-448 or GSK4428859A), alone or in combination with iberdomide with and without dexamethasone in participants with relapsed/refractory multiple myeloma (RRMM).

Key Dates

Start date
May 1, 2022
Status verified
Oct 2024
Primary completion
Nov 29, 2023
Completion
Nov 29, 2023

Study Design

Enrollment
16 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: A: Participants will receive EOS884448
    EOS884448 will be administered
  • Experimental: B: Participants will receive EOS884448 and iberdomide
    EOS884448 and iberdomide will be administered
  • Experimental: C: Participants will receive EOS884448, iberdomide and dexamethasone
    EOS884448, iberdomide and dexamethasone will be administered

Primary Outcome Measure

Number of participants with any adverse events (AEs) and serious adverse events (SAEs) [ Time Frame: From first study treatment administration up to 120 days after the last dose ]

Locations (4)

FacilityCityStateZIPSite coordinators
Banner MD AndersonGilbertArizona85234-
Eastern Connecticut Hematology & OncologyNorwichConnecticut06360-
Hackensack University Medical CenterHackensackNew Jersey07601-
Fred Hutchinson Cancer CenterSeattleWashington98109-

Find similar trials in Gilbert, AZ

By condition
Multiple myeloma
By specialty
OncologyBlood cancer
By research site
Banner MD Anderson· Gilbert, AZEastern Connecticut Hematology & Oncology· Norwich, CTHackensack University Medical Center· Hackensack, NJFred Hutchinson Cancer Center· Seattle, WA

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