A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver Cancer

Part of paid clinical trials in Los Angeles, California.

Sponsor
Bristol-Myers Squibb
Study ID
NCT05337137
Phase
PHASE1/PHASE2
Status
Completed

Conditions

  • Carcinoma, Hepatocellular

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Relatlimab — DRUG
    Specified dose on specified days
  • Nivolumab — DRUG
    Specified dose on specified days
  • Bevacizumab — DRUG
    Specified dose on specified days
  • Placebo — OTHER
    Specified dose on specified days

Study Details

The purpose of this study is to evaluate the safety and effectiveness of triplet therapy of nivolumab, relatlimab and bevacizumab versus nivolumab and bevacizumab in participants with untreated advanced/metastatic hepatocellular carcinoma (HCC).

Key Dates

Start date
May 5, 2022
Status verified
Jan 2026
Primary completion
Jul 5, 2025
Completion
Nov 18, 2025

Study Design

Enrollment
83 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm A: Relatlimab + Nivolumab + Bevacizumab
  • Experimental: Arm B: Placebo + Nivolumab + Bevacizumab

Primary Outcome Measure

Incidence of dose-limiting toxicities (DLTs) [ Time Frame: Up to 6 weeks ]

Locations (10)

FacilityCityStateZIPSite coordinators
Local Institution - 0039Los AngelesCalifornia90095-
Local Institution - 0042Los AngelesCalifornia90033-
Local Institution - 0034San FranciscoCalifornia94115-
Local Institution - 0030Washington D.C.District of Columbia20007-
Local Institution - 0059BaltimoreMaryland21231-
Local Institution - 0060BostonMassachusetts02114-
Local Institution - 0065BostonMassachusetts02215-
Local Institution - 0061New YorkNew York10065-
Local Institution - 0062The BronxNew York10461-
Local Institution - 0033MilwaukeeWisconsin53226-

Find similar trials in Los Angeles, CA

By research site
Local Institution - 0039· Los Angeles, CALocal Institution - 0042· Los Angeles, CALocal Institution - 0034· San Francisco, CALocal Institution - 0030· Washington D.C., DCLocal Institution - 0059· Baltimore, MDLocal Institution - 0060· Boston, MA

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