Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD)

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
EyePoint Pharmaceuticals, Inc.
Study ID
NCT05381948
Phase
PHASE2
Status
Completed

Conditions

  • Wet Age-related Macular Degeneration

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

This is a phase 2 randomized, double -masked study comparing the efficacy of EYP-1901 at 2 dose levels: 2060 microgram (mcg) and 3090 mcg against aflibercept.

Key Dates

First listed
May 19, 2022
Start date
Jun 30, 2022
Status verified
Oct 2025
Primary completion
Nov 29, 2023
Completion
Apr 24, 2024

Study Design

Enrollment
161 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: EYP-1901 2060 mcg
    EYP-1901 2060 mcg, single dose
  • Experimental: EYP-1901 3090 mcg
    EYP-1901 3090 mcg, single dose
  • Active Comparator: Aflibercept
    Aflibercept 2 milligram (mg) \[0.05 milliliter (mL)\] every 8 weeks

Primary Outcome Measure

Average Change in Best Corrected Visual Acuity (BCVA) From Baseline Averaged Over Weeks 28 and 32 [ Time Frame: Baseline (Day 1) and Weeks 28 and 32 ]

Locations (67)

FacilityCityStateZIPSite coordinators
EyePoint Investigative SitePhoenixArizona85053-
EyePoint Investigative SiteSpringdaleArkansas72762-
EyePoint Investigative SiteBeverly HillsCalifornia90211-
EyePoint Investigative SiteCampbellCalifornia95008-
EyePoint Investigative SiteEncinoCalifornia91436-
EyePoint Investigative SiteFullertonCalifornia92835-
EyePoint Investigative SiteGlendaleCalifornia91203-
EyePoint Investigative SiteHuntington BeachCalifornia92647-
EyePoint Investigative SiteIrvineCalifornia92697-
EyePoint Investigative SitePasadenaCalifornia91107-
EyePoint Investigative SitePowayCalifornia92064-
EyePoint Investigative SiteRedlandsCalifornia92373-
EyePoint Investigative SiteSacramentoCalifornia95825-
EyePoint Investigative SiteWalnut CreekCalifornia94598-
EyePoint Investigative SiteLakewoodColorado80228-
EyePoint Investigative SiteClearwaterFlorida33761-
EyePoint Investigative SiteCoral SpringsFlorida33067-
EyePoint Investigative SiteLakelandFlorida33805-
EyePoint Investigative SiteMelbourneFlorida32901-
EyePoint Investigative SiteMiamiFlorida33143-
EyePoint Investigative SitePensacolaFlorida32503-
EyePoint Investigative SiteSarasotaFlorida34239-
EyePoint Investigative SiteSt. PetersburgFlorida33711-
EyePoint Investigative SiteTampaFlorida33609-
EyePoint Investigative SiteWinter HavenFlorida33880-
EyePoint Investigative SiteMariettaGeorgia30060-
EyePoint Investigative Site‘AieaHawaii96701-
EyePoint Investigative SiteChicagoIllinois60616-
EyePoint Investigative SiteLemontIllinois60439-
EyePoint Investigative SiteCarmelIndiana46290-
EyePoint Investigative SiteWest Des MoinesIowa50266-
EyePoint Investigative SiteBaltimoreMaryland21209-
EyePoint Investigative SiteHagerstownMaryland21740-
EyePoint Investigative SiteOwings MillsMaryland21117-
EyePoint Investigative SiteBostonMassachusetts02114-
EyePoint Investigative SiteSpringfieldMassachusetts01107-
EyePoint Investigative SiteGrand RapidsMichigan49446-
EyePoint Investigative SiteSaint LouisMichigan55416-
EyePoint Investigative SiteSt LouisMissouri63128-
EyePoint Investigative SiteRenoNevada89502-
EyePoint Investigative SiteTeaneckNew Jersey07666-
EyePoint Investigative SiteGreat NeckNew York11021-
EyePoint Investigative SiteHauppaugeNew York11788-
EyePoint Investigative SiteLiverpoolNew York13088-
EyePoint Investigative SiteShirleyNew York11967-
EyePoint Investigative SiteAshevilleNorth Carolina28803-
EyePoint Investigative SiteWake ForestNorth Carolina27587-
EyePoint Investigative SiteEugeneOregon97401-
EyePoint Investigative SitePortlandOregon97239-
EyePoint Investigative SiteSpringfieldOregon97488-
EyePoint Investigative SiteCharlestonSouth Carolina29414-
EyePoint Investigative SiteWest ColumbiaSouth Carolina29169-
EyePoint Investigative SiteGermantownTennessee38138-
EyePoint Investigative SiteNashvilleTennessee37203-
EyePoint Investigative SiteAbileneTexas79606-
EyePoint Investigative SitesAustinTexas78750-
EyePoint Investigative SiteDallasTexas75231-
EyePoint Investigative SitesHoustonTexas77025-
EyePoint Investigative SiteMcAllenTexas78503-
EyePoint Investigative SitePlanoTexas75075-
EyePoint Investigative SiteSan AntonioTexas78240-
EyePoint Investigative SiteThe WoodlandsTexas77384-
EyePoint Investigative SiteSalt Lake CityUtah84107-
EyePoint Investigative SiteFairfaxVirginia22031-
EyePoint Investigative SiteLynchburgVirginia24502-
EyePoint Investigative SiteWarrentonVirginia20186-
EyePoint Investigative SiteSilverdaleWashington98383-

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