Study of SHR-8068 Combined With Adebrelimab and Bevacizumab in the Treatment of Advanced Hepatocellular Carcinoma
- Sponsor
- Suzhou Suncadia Biopharmaceuticals Co., Ltd.
- Study ID
- NCT05444088
- Phase
- PHASE1/PHASE2
- Status
- Unknown
Conditions
- Advanced Hepatocellular Carcinoma
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - 75 Years
- Healthy Volunteers
- Not accepted
Interventions
- Adebrelimab — DRUGintravenous infusion
- Bevacizumab — DRUGintravenous infusion
- SHR-8068 — DRUGintravenous infusion
Study Details
To evaluate the tolerability and safety of SHR-8068 in combination with Adebrelimab and Bevacizumab in subjects with advanced HCC; To evaluate the efficacy of SHR-8068 in combination with Adebrelimab and Bevacizumab in subjects with advanced HCC.
Key Dates
- First listed
- Jul 5, 2022
- Start date
- Aug 2, 2022
- Status verified
- Jun 2024
- Primary completion
- Jun 30, 2026
- Completion
- Jun 30, 2026
Study Design
- Enrollment
- 129 participants (estimated)
- Allocation
- RANDOMIZED
- Intervention model
- PARALLEL
- Primary purpose
- TREATMENT
Arms
- Experimental: Adebrelimab in combination with Bevacizumab
- Experimental: Adebrelimab in combination with Bevacizumab and SHR-8068 RP2D1
- Experimental: Adebrelimab in combination with Bevacizumab and SHR-8068 RP2D2
Primary Outcome Measure
Dose Limiting Toxicity [ Time Frame: The observation period is 21 days after the first dose ]
Central Contacts
- Xin Shi0518-82342973
- Ying Sun0518-82342973
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