Studies Into Touch in Healthy Humans to Provide Sensory Feedback in Prostheses

Sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Study ID
NCT05548322
Status
Recruiting
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Conditions

  • Aging
  • Amputation
  • Prosthesis User
  • Somatosensory Disorders
  • Tactile Disorders

Eligibility Criteria

Sex
ALL
Age
20 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Different surfaces to be touched — DEVICE
    The participant will touch various different surfaces and textures, including ones of different temperature and including solids and liquids.
  • Emotional state change — BEHAVIORAL
    The emotional state of the participant will be modulated by listening to music.
  • Electrical stimulation — DEVICE
    The participant will receive electrical stimulation of single nerve fibers (a few microamps) to artificially excite an individual afferent.

Study Details

Our sense of touch is essential to explore our environment and experience life and is based on signals from receptors in the body that are sensitive to different types of stimulation. The TACTHUM projects aims to investigate the fundamental firing of mechanoreceptors in the body to various external stimuli, with an end-aim to better understand the human somatosensory system and to apply this knowledge to provide comprehensive sensory feedback in prosthetics. We have a vast system of peripheral receptors in the skin and muscles that provide us with exquisitely detailed information about our everyday interactions. When there is injury to a body part, such as in amputation, there is a significant loss of somatosensory input. Prosthetic devices have greatly developmed in the past few years, especially with the introduction of useful sensory feedback. However, there is a lot to discover both about the workings of the somatosensory system and how to recreate this to give feedback in a prosthetic device. The main objective of the TACTHUM project is to understand how to recover and apply useful somatosensory feedback in prostheses for amputees. There are a number of other sub-objectives, to: 1. Determine how tactile mechanoreceptors encode the texture of natural surfaces during passive and active exploration. 2. Investigate how our sense of touch varies with emotional state. 3. Explore what happens to our sense of touch when we explore surfaces at different temperatures. 4. Understand the origin of our perception of humidity. 5. Investigate differences in the encoding of tactile information with age. 6. Determine the perceptions generated by the stimulation of single tactile afferents. 7. Study changes in spontaneous activity and responses to tactile stimulation on the residual limb of amputees. To accomplish these objectives, we will primarily use the technique of microneurography, in vivo recordings from peripheral nerves, to gain direct information about the firing of peripheral neurons in humans. In conjunction with this, we will use a variety of mechanical and thermal stimuli to excite somatosensory fibers and register the activity of other physiological and perceptual measures. This will allow us to gain a fuller understanding of how the incoming somatosensory signals are interpreted and processed. Overall, we aim to explore how more naturalistic tactile interactions are encoded and how these can be translated to provide realistic prosthetic feedback.

Key Dates

First listed
Sep 21, 2022
Start date
Apr 15, 2024
Status verified
Mar 2026
Primary completion
Oct 2, 2034
Completion
Nov 2, 2034

Study Design

Enrollment
210 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Study of tactile afferent responses to natural surfaces
  • Experimental: Modulation of touch according to the emotional state
  • Experimental: Effect of temperature on tactile sensitivity
  • Experimental: Origin of wetness perception
  • Experimental: Aging and tactile sensitivity
  • Experimental: Tactile perceptions induced by the stimulation of single sensory fibers
  • Experimental: Study of tactile feedback after amputation

Primary Outcome Measure

Microneurography recording [ Time Frame: Measured during the experiment (single event, max. 6 hours), during stimulation intervention ]

Central Contacts

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