Study of Lymphatic Dysfunction in Primary and Secondary Lymphedema

Sponsor
University Hospital, Toulouse
Study ID
NCT05629026
Status
Recruiting
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Conditions

  • Lymphedema

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Micro-biopsies — PROCEDURE
    Two micro-biopsies of limb tissue will be carried out, one on the lymphedema and one in the upper limb not affected.

Study Details

Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities and accumulation of undrained interstitial fluid/lymph that results in fibrosis and adipose tissue deposition in the affected area. It can be an inherited condition (primary lymphedema) or occurs after cancer surgery and lymph node removal (secondary lymphedema). It causes a significant morbidity and is a common disabling disease affecting more than 200 million people worldwide, however there is no curative treatment for primary or secondary lymphedema.

Key Dates

First listed
Nov 29, 2022
Start date
Feb 21, 2024
Status verified
Dec 2025
Primary completion
Feb 28, 2026
Completion
Feb 28, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: primary lymphoedema
    patients with primary lymphoedema
  • Experimental: secondary lymphoedema
    patients with secondary lymphoedema

Primary Outcome Measure

Number of RNA transcripts between lymphoedema limb and healthy limb [ Time Frame: Day 1 ]

Central Contacts

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