RP2/RP3 in Combination With Atezolizumab and Bevacizumab for the Treatment of Patients With CRC

Part of paid clinical trials in Los Angeles, California.

Sponsor
Replimune, Inc.
Study ID
NCT05733611
Phase
PHASE2
Status
Terminated

Conditions

  • MSS
  • Refractory Metastatic Colorectal Cancer
  • pMMR

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • RP2 — BIOLOGICAL
    Genetically modified herpes simplex type 1 virus
  • RP3 — BIOLOGICAL
    Genetically modified herpes simplex type 1 virus
  • atezolizumab — BIOLOGICAL
    anti-PD-L1 monoclonal antibody
  • bevacizumab — BIOLOGICAL
    anti-VEGF therapy

Study Details

This is an open-label, Phase 2 clinical trial evaluating therapy with an oncolytic immunotherapy (RP2 or RP3) in combination with atezolizumab and bevacizumab in patients with advanced Microsatellite Stable and Mismatch Repair Proficient Colorectal Carcinoma.

Key Dates

Start date
Jun 29, 2023
Status verified
Jan 2026
Primary completion
Aug 18, 2025
Completion
Aug 18, 2025

Study Design

Enrollment
5 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: RP2 and atezolizumab plus bevacizumab in advanced MSS and pMMR CRC
    RP2 will be injected by direct (including via colonoscope) or image-guided injection into injectable tumors (including subcutaneous, visceral, and nodal tumors).
  • Experimental: RP3 and atezolizumab plus bevacizumab in advanced MSS and pMMR CRC
    RP3 will be injected by direct (including via colonoscope) or image-guided injection into injectable tumors (including subcutaneous, visceral, and nodal tumors).

Primary Outcome Measure

Objective Response Rate (ORR) [ Time Frame: From Day 1 to documented progression of disease (up to 3 years) ]

Locations (2)

FacilityCityStateZIPSite coordinators
USC Norris Comprehensive Cancer CenterLos AngelesCalifornia90033-
University of Washington Seattle Cancer Care AllianceSeattleWashington98109-

Find similar trials in Los Angeles, CA

By research site
USC Norris Comprehensive Cancer Center· Los Angeles, CAUniversity of Washington Seattle Cancer Care Alliance· Seattle, WA

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