A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Eosinophilic Asthma

Part of paid clinical trials in Chandler, Arizona.

Sponsor
Areteia Therapeutics
Study ID
NCT05748600
Phase
PHASE3
Status
Active Not Recruiting

Conditions

  • Asthma Attack
  • Asthma; Eosinophilic
  • Eosinophilic Asthma

Eligibility Criteria

Sex
ALL
Age
12 Years - 99 Years
Healthy Volunteers
Not accepted

Interventions

  • Dexpramipexole Dihydrochloride — DRUG
    administration of dexpramipexole tablet
  • Placebo — DRUG
    administration of placebo tablet

Study Details

The purpose of this study is to evaluate dexpramipexole as an add-on oral therapy in participants with inadequately controlled eosinophilic asthma to evaluate improvements in lung function, asthma control, and quality of life. In addition, the study will further evaluate the safety and tolerability of dexpramipexole in participants with eosinophilic asthma.

Key Dates

First listed
Feb 28, 2023
Start date
Jan 30, 2023
Status verified
Aug 2025
Primary completion
Sep 30, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
600 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: 150 mg BID
    Dexpramipexole 150 mg oral tablet taken twice a day
  • Experimental: 75 mg BID
    Dexpramipexole 75 mg oral tablet taken twice a day
  • Placebo Comparator: Placebo
    Placebo oral tablet taken twice a day

Primary Outcome Measure

Change in pre-BD FEV₁ from baseline [ Time Frame: Day 1 (baseline, pre-dose), Weeks 20, 24 ]

Locations (146)

FacilityCityStateZIPSite coordinators
Research Site 40001-487ChandlerArizona85224-
Research Site 40001-462PeoriaArizona85381-
Research Site 40001-322SurpriseArizona85378-
Research Site 40001-374BakersfieldCalifornia93301-
Research Site 40001-227EncinitasCalifornia92024-
Research Site 40001-349Huntington BeachCalifornia92647-
Research Site 40001-485InglewoodCalifornia06410-
Research Site 40001-440La PalmaCalifornia90623-
Research Site 40001-357LancasterCalifornia93534-
Research Site 40001-089Los AngelesCalifornia90048-
Research Site 40001-362Mission ViejoCalifornia92691-
Research Site 40001-449NapaCalifornia94558-
Research Site 40001-043Newport BeachCalifornia92663-
Research Site 40001-062Newport BeachCalifornia92660-
Research Site 40001-380ReddingCalifornia96001-
Research Site 40001-434San DiegoCalifornia92123-
Research Site 40001-088San JoseCalifornia95117-
Research Site 40001-359UplandCalifornia91756-
Research Site 40001-003West CovinaCalifornia91790-
Research Site 40001-419WestminsterCalifornia92683-
Research Site 40001-425AuroraColorado80014-
Research Site 40001-353Colorado SpringsColorado80907-
Research Site 40001-385Wheat RidgeColorado80033-
Research Site 40001-048AventuraFlorida33180-
Research Site 40001-005BrandonFlorida33511-
Research Site 40001-051BrandonFlorida33511-
Research Site 40001-029Coral GablesFlorida33134-
Research Site 40001-350GainesvilleFlorida32607-
Research Site 40001-014Greenacres CityFlorida33467-
Research Site 40001-054HialeahFlorida33012-
Research Site 40001-067HialeahFlorida33016-
Research Site 40001-020HomesteadFlorida33030-
Research Site 40001-002KissimmeeFlorida34746-
Research Site 40001-015KissimmeeFlorida34744-
Research Site 40001-086Loxahatchee GrovesFlorida33470-
Research Site 40001-318MaitlandFlorida32751-
Research Site 40001-001MiamiFlorida33135-
Research Site 40001-024MiamiFlorida33184-
Research Site 40001-026MiamiFlorida33155-
Research Site 40001-059MiamiFlorida33144-
Research Site 40001-065MiamiFlorida33173-
Research Site 40001-066MiamiFlorida33126-
Research Site 40001-288MiamiFlorida33165-
Research Site 40001-338Miami BeachFlorida33169-
Research Site 40001-348OcalaFlorida34471-
Research Site 40001-293OrlandoFlorida32819-
Research Site 40001-429PlantationFlorida33317-
Research Site 40001-351SarasotaFlorida34239-
Research Site 40001-069St. PetersburgFlorida33713-
Research Site 40001-370TallahasseeFlorida32308-
Research Site 40001-004TampaFlorida33607-
Research Site 40001-319VieraFlorida32940-
Research Site 40001-142AdairsvilleGeorgia30103-
Research Site 40001-075AugustaGeorgia30909-
Research Site 40001-018ColumbusGeorgia31904-
Research Site 40001-452DunwoodyGeorgia30350-
Research Site 40001-483East PointGeorgia30344-
Research Site 40001-366LilburnGeorgia30047-
Research Site 40001-423SavannahGeorgia31406-
Research Site 40001-090BerwynIllinois60402-
Research Site 40001-343ChicagoIllinois60607-
Research Site 40001-358NormalIllinois61761-
Research Site 40001-135River ForestIllinois60305-
Research Site 40001-403SkokieIllinois60077-
Research Site 40001-036ElwoodIndiana46036-
Research Site 40001-347LouisvilleKentucky40202-
Research Site 40001-019OwensboroKentucky42301-
Research Site 40001-437AlexandriaLouisiana71303-
Research Site 40001-313MarreroLouisiana70072-
Research Site 40001-352ZacharyLouisiana70791-
Research Site 40001-417AnnapolisMaryland21401-
Research Site 40001-466BaltimoreMaryland21237-
Research Site 40001-456Takoma ParkMaryland20912-
Research Site 40001-055White MarshMaryland21162-
Research Site 40001-468Fall RiverMassachusetts02723-
Research Site 40001-427DearbornMichigan48126-
Research Site 40001-006FlintMichigan48504-
Research Site 40001-148FlintMichigan48507-
Research Site 40001-463Rochester HillsMichigan48307-
Research Site 40001-442SouthfieldMichigan48034-
Research Site 40001-372WarrenMichigan48088-
Research Site 40001-421MankatoMinnesota56001-
Research Site 40001-083ColumbiaMissouri65203-
Research Site 40001-074Saint CharlesMissouri63301-
Research Site 40001-046St LouisMissouri63110-
Research Site 40001-409MissoulaMontana59808-
Research Site 40001-448LincolnNebraska68510-
Research Site 40001-404OmahaNebraska68798-
Research Site 40001-473Las VegasNevada89109-
Research Site 40001-387BrickNew Jersey08724-
Research Site 40001-363EdisonNew Jersey08817-
Research Site 40001-457Jersey CityNew Jersey07304-
Research Site 40001-355Toms RiverNew Jersey08755-
Research Site 40001-050East AmherstNew York14051-
Research Site 40001-412Great NeckNew York11021-
Research Site 40001-047HawthorneNew York10532-
Research Site 40001-369New YorkNew York10029-
Research Site 40001-455New YorkNew York10016-
Research Site 40001-398CharlotteNorth Carolina28277-
Research Site 40001-408CharlotteNorth Carolina28273-
Research Site 40001-039GastoniaNorth Carolina28054-
Research Site 40001-435GreenvilleNorth Carolina17834-
Research Site 40001-111HuntersvilleNorth Carolina28078-
Research Site 40001-382RaleighNorth Carolina27610-
Research Site 40001-439Rocky MountNorth Carolina27804-
Research Site 40001-283Winston-SalemNorth Carolina21704-
Research Site 40001-010CincinnatiOhio45236-
Research Site 40001-013CincinnatiOhio45219-
Research Site 40001-034CincinnatiOhio45215-
Research Site 40001-413ClevelandOhio44106-
Research Site 40001-017DaytonOhio45424-
Research Site 40001-063ToledoOhio43617-
Research Site US-40001-038EdmondOklahoma73034-
Research Site 40001-079Oklahoma CityOklahoma73120-
Research Site 40001-386Oklahoma CityOklahoma73102-
Research Site 40001-027Grants PassOregon97527-
Research Site 40001-337PortlandOregon97202-
Research Site 40001-395HersheyPennsylvania17033-
Research Site 40001-327PhiladelphiaPennsylvania19140-
Research Site 40001-032ColumbiaSouth Carolina29204-
Research Site 40001-025GreenvilleSouth Carolina29651-
Research Site 40001-430Rock HillSouth Carolina29732-
Research Site 40001-073SpartanburgSouth Carolina29303-
Research Site 40001-438DicksonTennessee37055-
Research Site 40001-414FranklinTennessee37067-
Research Site 40001-334AllenTexas75013-
Research Site 40001-068AmarilloTexas79124-
Research Site 40001-023DallasTexas75230-
Research Site 40001-028DallasTexas75235-
Research Site 40001-415DallasTexas75246-
Research Site 40001-304DeSotoTexas75115-
Research Site 40001-418FriscoTexas75034-
Research Site 40001-064HoustonTexas77074-
Research Site 40001-085HoustonTexas77099-
Research Site 40001-424KerrvilleTexas78028-
Research Site 40001-295McKinneyTexas75069-
Research Site 40001-304Red OakTexas75154-
Research Site 40001-377San AntonioTexas78258-
Research Site 40001-335Sugar LandTexas77479-
Research Site 40001-258MurrayUtah84107-
Research Site 40001-333Pleasant ViewUtah84404-
Research Site 40001-340BurkeVirginia22015-
Research Site 40001-394WilliamsburgVirginia23188-
Research Site 40001-339GreenfieldWisconsin53228-
Research Site 40001-433La CrosseWisconsin54601-
Research Site 40001-443La CrosseWisconsin54601-

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