A Cohort Study on Anti-microbial Stewardship in PICU

Sponsor
Children's Hospital of Fudan University
Study ID
NCT05862688
Status
Not Yet Recruiting

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Conditions

  • Infections

Eligibility Criteria

Sex
ALL
Age
1 Month - 18 Years
Healthy Volunteers
Not accepted

Interventions

  • antimicrobial therapy — OTHER
    antimicrobial therapy

Study Details

Appropriate antimicrobial therapy is essential to ensuring positive patient outcomes. Inappropriate or suboptimal utilization of antibiotics can lead to increased length of stay, multidrug-resistant infections, and mortality. Critically ill intensive care patients are at risk of antibiotic failure and secondary infections associated with incorrect antibiotic use. Initiating effective therapy for infections based upon patients' risk factors, collection of appropriate cultures, daily evaluation of clinical status, and laboratory data, including antibiotic time outs, and shortened duration of therapy are ways to improve patients outcomes. Antimicrobial stewardship teams can assist ICU providers in managing and implementing these tactics. ICUs would benefit from employing empiric guidelines for antibiotic use, collecting appropriate specimens and implementing molecular diagnostics, optimizing the dosing of antibiotics, and reducing the duration of total therapy.

Key Dates

First listed
May 17, 2023
Start date
Jul 1, 2026
Status verified
Feb 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
1,000 participants (estimated)

Arms

  • Arm: Infection
    patients with infection
  • Arm: non-infection
    patients without infection

Primary Outcome Measure

survival rate [ Time Frame: 21 days after ICU admission ]

Central Contacts

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