Oral Health and Adverse Pregnancy Complications

Sponsor
University Hospital Bispebjerg and Frederiksberg
Study ID
NCT06110143
Status
Recruiting
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Conditions

  • Gestational Diabetes
  • Inflammation
  • Periodontal Diseases
  • Preeclampsia
  • Pregnancy Complications
  • Pregnancy Preterm

Eligibility Criteria

Sex
FEMALE
Age
16 Years - 48 Years
Healthy Volunteers
Accepted

Interventions

  • Periodontal treatment — OTHER
    Periodontal treatment

Study Details

Pregnant women are susceptible to develop periodontitis, but these oral health changes related to pregnancy are often neglected. Periodontitis is accompanied by a low-grade systemic inflammation and can be harmful to the general health of the woman, contribute to pre-term birth and adversely influence the future health and metabolism of the offspring. Despite this, studies indicate that 40% of Danish women in childbearing age do not visit a dentist regularly. The PROBE controlled intervention study will investigate the beneficial effect of treatment of periodontal disease during pregnancy on fetal growth, preterm delivery and birth weight.

Key Dates

First listed
Oct 31, 2023
Start date
Nov 13, 2021
Status verified
Mar 2025
Primary completion
Nov 30, 2025
Completion
May 31, 2026

Study Design

Enrollment
600 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Other: PrePROBE
    Periodontal treament during pregnancy
  • Other: PostPROBE
    Peridontal treatment postpartum

Primary Outcome Measure

Prevalence of preterm birth [ Time Frame: 18 months ]

Central Contacts

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