A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Part of paid clinical trials in West Hollywood, California.

Sponsor
Bristol-Myers Squibb
Study ID
NCT06112743
Phase
PHASE4
Status
Active Not Recruiting

Conditions

  • Cardiomyopathy, Hypertrophic

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Mavacamten — DRUG
    Specified dose on specified days

Study Details

The purpose of this study is to evaluate the mavacamten impact on myocardial structure with cardiac magnetic resonance imaging (CMR) in adult participants with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) \[New York Heart Association (NYHA) Functional Class II or III\].

Key Dates

Start date
Jan 24, 2024
Status verified
Sep 2025
Primary completion
Jul 9, 2026
Completion
Jul 9, 2026

Study Design

Enrollment
63 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Mavacamten

Primary Outcome Measure

Composite of maximum left atrial volume index (LAVI) and left ventricular mass index (LVMI) at Week 48 [ Time Frame: At week 48 ]

Locations (7)

FacilityCityStateZIPSite coordinators
Local Institution - 0087West HollywoodCalifornia90048-1804-
Local Institution - 0003AtlantaGeorgia30309-
Local Institution - 0093BostonMassachusetts02114-
Local Institution - 0090ClevelandOhio44106-
Local Institution - 0086PittsburghPennsylvania15212-4756-
Local Institution - 0017HoustonTexas77030-
Local Institution - 0035MurrayUtah84107-5701-

Find similar trials in West Hollywood, CA

By research site
Local Institution - 0087· West Hollywood, CALocal Institution - 0003· Atlanta, GALocal Institution - 0093· Boston, MALocal Institution - 0090· Cleveland, OHLocal Institution - 0086· Pittsburgh, PALocal Institution - 0017· Houston, TX

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