MRE for Assessment of Histopathological Growth Patterns in Colorectal Liver Metastases

Sponsor
Shengjing Hospital
Study ID
NCT06208397
Status
Recruiting
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Conditions

  • Metastatic Colorectal Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Magnetic Resonance Elastography and routine MRI — DIAGNOSTIC_TEST
    Assessed boundary conditions through MRE-base SII before surgery and recorded HGP of tumor after surgery.

Study Details

The goal of this study is to investigate the value of MR elastography-based SII as a means of detecting HGP noninvasively in patients with pathology-proven CRLM. MRE will provide a direct measure of tumor-liver adhesion to investigate the relationship between imaging findings and pathophysiological changes in the Liver.

Key Dates

First listed
Jan 17, 2024
Start date
Dec 24, 2023
Status verified
May 2025
Primary completion
Dec 24, 2025
Completion
Dec 24, 2026

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Experimental: Diagnostic (MRE)
    Patients undergo a preoperative routine MRI scan and MRE the day before their scheduled surgery to assess OSS and NOSS. After surgery, the HGP of tumor will be assessed by H\&E-stained sections.

Primary Outcome Measure

Radiological assessment of CRLM [ Time Frame: Baseline to 6 weeks ]

Central Contacts

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