Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Ocular Therapeutix) (Axitinib Implant) in Subjects With Neovascular Age-Related Macular Degeneration

Part of paid clinical trials in Gilbert, Arizona.

Sponsor
Ocular Therapeutix, Inc.
Study ID
NCT06223958
Phase
PHASE3
Status
Active Not Recruiting

Conditions

  • Neovascular Age-Related Macular Degeneration

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • OTX-TKI (axitinib implant) — DRUG
    Intravitreal Injection of OTX-TKI (axitinib implant)
  • Aflibercept — DRUG
    Injection of 2mg (0.05mL) of aflibercept

Study Details

Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (axitinib implant) in Subjects with Neovascular Age-Related Macular Degeneration

Key Dates

Start date
Jan 29, 2024
Status verified
Apr 2025
Primary completion
Apr 29, 2026
Completion
Sep 27, 2027

Study Design

Enrollment
344 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: OTX-TKI (axitinib implant)
  • Other: Control

Primary Outcome Measure

Best corrected visual acuity (BCVA) [ Time Frame: Up to 36 Weeks ]

Locations (97)

FacilityCityStateZIPSite coordinators
Associated Retina Consultants - GilbertGilbertArizona85297-
Associated Retina Consultants - PhoenixPhoenixArizona85020-
Retinal Research InstitutePhoenixArizona85053-
Retina Macula Institute of ArizonaScottsdaleArizona85255-
CA CRC California Retina ConsultantsBakersfieldCalifornia93103-
The Retina Partners - EncinoEncinoCalifornia91436-
Retina Consultants of Orange County - FullertonFullertonCalifornia92835-
Atlantis EyecareHuntington BeachCalifornia92647-
Lakeside Vision Center - IrvineIrvineCalifornia92604-
Retina-Vitreous Associates Medical Group - Los AngelesLos AngelesCalifornia90017-4886-
CA RCMG Retinal Consultants Medical Group, Inc.ModestoCalifornia95356-
Retina Sacramento MSO, LLCModestoCalifornia95356-
Kaiser Permanente Division of ResearchOaklandCalifornia94611-
CA CRC California Retina ConsultantsOxnardCalifornia93103-
Stanford University School of Medicine, Byers Eye InstitutePalo AltoCalifornia94303-
AzulVisionPasadenaCalifornia91107-
Doheny Eye CenterPasadenaCalifornia91105-
Orange County Retina Medical GroupSanta AnaCalifornia92705-
California Retina Consultants (CRC) - Santa BarbaraSanta BarbaraCalifornia93103-4211-
Macula Retina Vitreous CenterTorranceCalifornia90505-
Bay Area Retina Associates, A Medical GroupWalnut CreekCalifornia94598-
Retina Consultants of Southern Colorado - Colorado SpringsColorado SpringsColorado80909-
RSC Research, PLLCDenverColorado80210-
Colorado Retina Associates (CRA) - LakewoodLakewoodColorado80228-
Retina Group of New England, PCWaterfordConnecticut06385-
The Macula Center - Clearwater Office (Suncoast Retina Consultants, LLC)ClearwaterFlorida33761-
Rand Eye InstituteDeerfield BeachFlorida33064-
Speciality Retina CenterDeerfield BeachFlorida33064-
Retina Group of Florida - Fort LauderdaleFort LauderdaleFlorida33308-1909-
Florida Retina Institute - Lake MaryLake MaryFlorida32746-2175-
Florida Retina Consultants - LakelandLakelandFlorida33805-
South Florida Retina InstituteMiamiFlorida33145-
Retina Specialty Institute - PensacolaPensacolaFlorida32503-2030-
MedEye Associates - MiamiSouth MiamiFlorida33143-
Retina Vitreous Associates of Florida (RVA) - Saint PetersburgSt. PetersburgFlorida33711-1141-
Retina Associates of Florida LLC Tampa MacDillTampaFlorida33609-
Retina Vitreous Associates of Florida - TampaTampaFlorida33607-
Southeast Retina Center, P.C. - AugustaAugustaGeorgia30909-6440-
Illinois Eye and Ear Infirmary at UI Health UICChicagoIllinois60612-
Illinois Retina Associates, S.C. - Lincoln ParkChicagoIllinois60657-7227-
University Retina and Macula Associates, P.C.Oak ForestIllinois60452-
Springfield ClinicSpringfieldIllinois62703-
IN AVRUC Associated Vitreoretinal and Uveitis ConsultantsCarmelIndiana46290-
Retina Partners MidwestIndianapolisIndiana46290-1166-
Wolfe Eye ClinicWest Des MoinesIowa50266-7705-
Maine Eye Center - Marginal Way CampusPortlandMaine04101-2438-
The Wilmer Eye InstituteBaltimoreMaryland21287-
Cumberland Valley Retina ConsultantsHagerstownMaryland21740-
Mid Atlantic Retina Specialists - HagerstownHagerstownMaryland21740-5846-
Henry Ford HospitalDetroitMichigan48202-
Associated Retinal Consultants P.C. (ARC) - Royal OakRoyal OakMichigan48073-
Retina Consultants of MinnesotaEdinaMinnesota55435-
Mississippi Baptist Medical CenterJacksonMississippi39202-2064-
Pepose Vision InstituteChesterfieldMissouri63017-
Retina Research Institute, LLCSt LouisMissouri63144-1317-
Sierra Eye AssociatesRenoNevada89502-1605-
The Retina Center Of New Jersey, LLC - BloomfieldBloomfieldNew Jersey07003-
Long Island Vitreoretinal Consultants (VRC) - HauppaugeHauppaugeNew York11788-
Retina-Vitreous Surgeons of Central New YorkLiverpoolNew York13088-
NY LIVRC Long Island Vitreoretinal ConsultantsShirleyNew York11967-
Asheville Eye Associates (AEA) - Retinal OfficeAshevilleNorth Carolina28803-
Duke University Health System - Duke Eye Center Of North DurhamDurhamNorth Carolina27705-
Retina Associates of Cleveland, Inc. - BeachwoodBeachwoodOhio44122-
Retina Associates of ClevelandClevelandOhio44130-
Retina Associates of Cleveland, Inc. - YoungstownYoungstownOhio44505-
Erie Retina ResearchEriePennsylvania16507-
Palmetto Retina CenterAikenSouth Carolina29802-
Charleston Neuroscience Institute LLC - BeaufortBeaufortSouth Carolina29902-
SC CNI Retina Consultants of CharlestonBeaufortSouth Carolina29902-
Charleston Neuroscience Institute LLC - CharlestonCharlestonSouth Carolina29414-
Palmetto Retina CenterFlorenceSouth Carolina29501-
Charleston Neuroscience InstituteLadsonSouth Carolina29456-
Retina Consultants of Charleston - Mount PleasantMt. PleasantSouth Carolina29464-
Palmetto Retina CenterWest ColumbiaSouth Carolina29169-2429-
Black Hills Regional Eye Institute (BHREI)Rapid CitySouth Dakota57701-7374-
Vance Thompson VisionSioux FallsSouth Dakota57108-
Charles Retina Institute PCGermantownTennessee38138-2405-
Tennessee Retina, PC - Nashville - Centennial Professional Plaza LocationNashvilleTennessee37203-1596-
West Texas Retina Consultants (WTRC) - Abilene (Ophthalmology Specialists of Texas, PA)AbileneTexas79606-
Texas Retina Associates (TRA) - ArlingtonArlingtonTexas76012-2505-
Austin Retina Associates, PLLCAustinTexas78705-1169-
Keystone ResearchAustinTexas78731-
Retina Consultants of Austin PA (RCA) - Central AustinAustinTexas78705-1023-
Retina Research Center (RRC)AustinTexas78750-2302-
Retina Consultants of Texas BeaumontBeaumontTexas77707-
Retina Group, Inc. d/b/a Retina Consultants of America (Retina Consultants of Texas)BellaireTexas77401-
Star Vision ConsultantsBurlesonTexas76028-
Texas Retina CenterHoustonTexas77030-
Retina Consultants of Texas - KatyKatyTexas77494-
Medical Center Ophthalmology Associates (MCOA) - Northwest Clinic LocationSan AntonioTexas78240-1502-
Retinal Consultants of Texas - San Antonio Medical CenterSan AntonioTexas78240-
TX RCTX Retina Consultants of TexasSan AntonioTexas78240-
Retina Consultants of HoustonThe WoodlandsTexas77384-
Retina Associates of Utah, P.C - Intermountain Medical Center LocationSalt Lake CityUtah84107-6767-
Wagner Macula & Retina Center - Norfolk, VA OfficeNorfolkVirginia23502-3933-
Vistar Eye Center Vision and Surgery SpecialistsRoanokeVirginia24019-
Eye Clinic of WisconsinWausauWisconsin54403-

Find similar trials in Gilbert, AZ

By research site
Associated Retina Consultants - Gilbert· Gilbert, AZAssociated Retina Consultants - Phoenix· Phoenix, AZRetinal Research Institute· Phoenix, AZRetina Macula Institute of Arizona· Scottsdale, AZCA CRC California Retina Consultants· Bakersfield, CAThe Retina Partners - Encino· Encino, CA

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