Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease

Sponsor
University of Alberta
Study ID
NCT06325280
Status
Recruiting
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Conditions

  • Congenital Heart Disease
  • Heart Transplantation
  • Pediatric ALL

Eligibility Criteria

Sex
ALL
Age
10 Years - 18 Years
Healthy Volunteers
Not accepted

Interventions

  • Exercise cardiac MRI Assessment — DIAGNOSTIC_TEST
    Participants will undergo a standard cardiac MRI to assess resting ventricular structure and function then complete an exercise cardiac MRI assessment using an MRI-compatible stepping ergometer.
  • Cardiopulmonary Exercise Test — DIAGNOSTIC_TEST
    Cardiopulmonary exercise testing will be performed using a cycle ergometer. Consistent with standard guidelines, workload will progressively increase (10W ramp protocol) such that peak oxygen consumption (VO2peak) is achieved within 8-12 minutes. VO2peak, VO2 at anaerobic threshold, peak power output (PPO), ventilation/carbon dioxide production (VE/VCO2) slope, peak heart rate (HR), and HR recovery at 1- and 3-minutes will be recorded. VO2peak will be converted to age-, weight, and sex-specific norms and a %predicted value.

Study Details

There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function.

Key Dates

First listed
Mar 22, 2024
Start date
Jan 20, 2025
Status verified
Mar 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
20 participants (estimated)

Arms

  • Arm: Congenital heart disease
    Participants aged 10-18 years who have congenital heart disease.
  • Arm: Heart transplant recipient
    Participants aged 10-18 years who have recieved a heart transplant.

Primary Outcome Measure

MRI assessment of cardiac structure at rest [ Time Frame: Baseline ]

Central Contacts

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