Lymphedema, Low-grade Inflammation and the Vasculature in Turner Syndrome

Sponsor
University of Aarhus
Study ID
NCT06325618
Status
Recruiting
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Conditions

  • Cardiovascular Diseases
  • Inflammation
  • Lymphedema
  • Turner Syndrome

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 100 Years
Healthy Volunteers
Accepted

Interventions

  • No intervention other than obtaining biopsies — OTHER
    Skin, fat, and muscle biopsies will be obtained
  • Indocyanine green (ICG) — DRUG
    Indocyanine green will be injected to evaluate the lymphatic system.

Study Details

100 women with karyotype verified TS, previously examined at 4 study visits during a 19-year period will be asked to participate in a 5th study visit. Healthy age-matched females will be included as controls in a ratio 2:1. The aim is to examine and quantify the cardiovascular and lymphatic system in women with TS. The investigators will study a possible causal mechanism between the known pathologic phenotype and alterations in these systems to understand, prevent or treat the life-threatening complications in TS.

Key Dates

First listed
Mar 22, 2024
Start date
Jan 8, 2024
Status verified
Jan 2024
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
150 participants (estimated)

Arms

  • Arm: Turner Syndrome
    Women with karyotype verified Turner Syndrome n=100
  • Arm: Female controls
    Healthy, age-matched controls n=50

Primary Outcome Measure

Grade dysfunction of clinical and subclinical lymphedema using Indocyanine Green Lymphography and Magnetic Resonance Lymphangiography. [ Time Frame: 3 year ]

Central Contacts

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