Mechanics of Human Pre Implantation Development

Sponsor
Assistance Publique - Hôpitaux de Paris
Study ID
NCT06408389
Status
Not Yet Recruiting

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Conditions

  • Infertility

Eligibility Criteria

Sex
ALL
Age
18 Years - 43 Years
Healthy Volunteers
Not accepted

Study Details

The time-lapse is a closed tri-gas incubator of the latest generation that provides optimal and stable culture conditions for the culture of embryos in In Vitro Fertilization (IVF). The integration of a camera within this incubator allows for continuous image capture, thus facilitating the monitoring of the entire embryonic development, from the day of fertilization to the moment of transfer into the uterus. The contribution of the time-lapse system allows an evaluation of the embryos not only by their morphology, but also by their cell division kinetics, both being direct markers of cell mechanics. Together, these morpho-kinetic data finally allow for the best identification of embryos with greater implantation potential. Time-lapse imaging represents a further step towards an objective assessment of the embryo, but inter- and intra-embryologist variations in annotations partly compromise this objectivity. In addition, many decision algorithms based on the evaluation of morpho-kinetic parameters have been developed, but the lack of reproducibility from one Assisted Reproductive Technology (ART) center to another is a hindrance to the generalization of any particular algorithm. The aim of this retrospective study is to determine morpho-kinetic factors predictive of implantation using machine learning and to link these factors to human embryo mechanistic properties.

Key Dates

First listed
May 10, 2024
Start date
Nov 30, 2025
Status verified
Sep 2025
Primary completion
Nov 30, 2028
Completion
Nov 30, 2028

Study Design

Enrollment
1,500 participants (estimated)

Primary Outcome Measure

Prediction of embryo implantation by the machine learning algorithm from embryo morphokinetic parameters and patient health data. [ Time Frame: 2 years ]

Central Contacts

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