Transient Receptor Potential Channels

Part of paid clinical trials in University Park, Pennsylvania.

Sponsor
Penn State University
Study ID
NCT06444594
Phase
EARLY_PHASE1
Status
Enrolling By Invitation

Conditions

  • Aging

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • TRPM8 Agonist — DRUG
    menthol gel 4-10%
  • TRPV1 Agonist — DRUG
    camphor gel 5-20%
  • TRPV4 Agonist — DRUG
    capsaicin gel 0.05-1%%
  • TRPM8, TRPV4, TRPV1 Agonists — DRUG
    menthol (4-10%), capsaicin (0.05-1%), camphor (5-20%)
  • Vehicle gel — OTHER
    Inactive vehicle gel

Study Details

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

Key Dates

First listed
Jun 5, 2024
Start date
Jul 17, 2024
Status verified
Jul 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
45 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Vehicle Gel
    Non-active topical gel
  • Experimental: Transient Receptor Potential (M8) Agonist
    Topical menthol gel applied once at 10%
  • Experimental: Transient Receptor Potential (V4) Agonist
    Topical capsaicin gel applied once at 0.05%
  • Experimental: Transient Receptor Potential (V1) Agonist
    Topical camphor gel applied once at 0.6%
  • Experimental: Transient Receptor Potential M8 V4 V1 Agonist
    Topical menthol 10%, capsaicin 0.05%, camphor 0.6% applied once
  • No Intervention: no gel
    no gel comparison

Primary Outcome Measure

Skin blood flow during slow local heating [ Time Frame: 75 minutes ]

Locations (1)

FacilityCityStateZIPSite coordinators
Noll LaboratoryUniversity ParkPennsylvania16802-

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Noll Laboratory· University Park, PA

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