Pathogenesis of Postoperative Infections and Biomarkers for Early Diagnosis of it

Sponsor
National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Study ID
NCT06513598
Status
Recruiting
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Conditions

  • Complication of Surgical Procedure
  • Infections

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Major visceral surgery for gastrointestinal cancer — PROCEDURE
    This is a longitudinal observational study of the patients undergoing major visceral surgery for gastrointestinal cancer. Biological samples will be collected to compare gastrointestinal and infection site metastases and develop biomarkers for postoperative infections.

Study Details

Infections remain a prevalent complication after major abdominal surgery. The common belief that most surgical site infections (SSIs) following elective surgery with modern antiseptic techniques are due to intraoperative contamination is still not confirmed. Therefore, alternative mechanisms for SSI development, such as the Trojan Horse theory-which suggests that pathogens from distant sites like the gastrointestinal tract may cause postoperative infections-should be explored. This study aims to analyze the preoperative microbiome of surgical patients' gut and oral cavities and assess whether microorganisms found there are present at the infection site. Additionally, this study will investigate a panel of biomarkers for predicting postoperative infections.

Key Dates

First listed
Jul 22, 2024
Start date
Jul 1, 2024
Status verified
Jul 2024
Primary completion
May 30, 2025
Completion
May 1, 2029

Study Design

Enrollment
200 participants (estimated)

Primary Outcome Measure

The similarity in composition between the infection site microbiome and the gut/oral microbiome. [ Time Frame: 0 to 30 days ]

Central Contacts

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