Evaluation of Clinical Decision Support in Opioid Tapering

Sponsor
University of Colorado, Denver
Study ID
NCT06527079
Status
Not Yet Recruiting

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Conditions

  • Harm Reduction
  • Medication Abuse
  • Opioid Overdose
  • Opioid Prescribing
  • Opioid Use Disorder
  • Prevention

Eligibility Criteria

Sex
ALL
Age
12 Years - 89 Years
Healthy Volunteers
Accepted

Interventions

  • Opioid Tapering Pathway Clinical Decision Support (CDS) — OTHER
    Clinical decision support in the form of an electronic health record (EHR)-integrated, provider facing notification suggesting the provider utilize a clinical care pathway that provides resources and decision support in opioid tapering in line with CDC guidelines.

Study Details

The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the risk of withdrawal symptoms, overdose, and to promote tolerance of the tapering. This project will evaluate a clinical decision support (CDS) tool in the form of a clinical care pathway that gives providers information, recommendations, and educational material on strategies for opioid tapering. Primary care providers will be randomized at the clinic location to a control arm or intervention arm. The control arm will have the clinical care pathway available, but will not be reminded of the pathway when tapering a patient. The intervention arm will receive a nudge when prescribing a tapering opioid strategy to a patient to use the clinical care pathway. The rate of opioid tapering in line with CDC guidelines will be examined as well as long-term patient outcomes of opioid overdose or poisoning using existing patient health records. The study period will be approximately 18 months.

Key Dates

First listed
Jul 30, 2024
Start date
Aug 31, 2026
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Jun 30, 2027

Study Design

Enrollment
200,000 participants (estimated)

Arms

  • Arm: Usual Care
    Control group to enable tracking of temporal changes in prescribing. Providers will not see any alert.
  • Arm: CDS Notification
    Providers will see a clinical decision support tool within the electronic health record when treating a patient who may benefit from or is currently tapering opioid medications to encourage the provider to use a clinical care pathway that provides resources and decision support in tapering.

Primary Outcome Measure

Percentage of encounters tapering within CDC guidelines [ Time Frame: 18 months ]

Central Contacts

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