Studying Phenotypes of Gestational Diabetes Mellitus in an Asian Pregnant Cohort

Sponsor
National University Health System, Singapore
Study ID
NCT06542718
Status
Recruiting
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Conditions

  • Birth Weight
  • Gestational Diabetes
  • Insulin Resistance, Diabetes
  • Intergenerational Relations
  • Pregnancy Complications
  • Pregnancy Related

Eligibility Criteria

Sex
FEMALE
Age
21 Years - 45 Years
Healthy Volunteers
Not accepted

Study Details

Gestational diabetes mellitus (GDM) is a transient hyperglycemic condition identified during pregnancy in women without a history of chronic diabetes. Evidence indicates that GDM can lead to various adverse health outcomes, including preterm birth, progression to pre-diabetes, and type 2 diabetes after delivery in mothers. Notably, GDM is becoming increasingly prevalent among Asian pregnant women due to rising rates of overweight and obesity, as well as genetic susceptibility. Despite growing recognition of GDM, its treatment efficiency and efficacy remain poor, primarily due to its heterogeneity, which is underpinned by various pathophysiological mechanisms. Therefore, a better understanding of GDM heterogeneity can aid clinicians in providing more targeted treatment and follow-up strategies for GDM mothers. This study aims to define GDM phenotypes based on in vivo cardio-metabolic profiles and treatment response during pregnancy, utilizing advanced technologies such as continuous glucose profiling and untargeted metabolite profiling. In this proposed 3-year pregnancy cohort study, the investigators will recruit 800 overweight or obese Asian pregnant women in early pregnancy, without a history of diabetes, and follow them through to delivery. The goal of the study is to develop systematic antenatal and postnatal screening, treatment, and intervention guidelines for mothers with GDM.

Key Dates

First listed
Aug 7, 2024
Start date
Oct 3, 2022
Status verified
May 2025
Primary completion
Jun 30, 2026
Completion
Jul 1, 2026

Study Design

Enrollment
800 participants (estimated)

Primary Outcome Measure

IADPSG (International Association of Diabetes and Pregnancy Study Groups)-defined Gestational Diabetes Mellitus (GDM) [ Time Frame: 3 years ]

Central Contacts

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