STunning in Acute Myocardial Infarction - BAS

Sponsor
Vastra Gotaland Region
Study ID
NCT06562582
Phase
PHASE4
Status
Recruiting
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Conditions

  • Myocardial Infarct

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Bisoprolol Oral Tablet — DRUG
    Timing of drug intervention after PCI
  • Ramipril Oral Product — DRUG
    Timing of drug intervention after PCI
  • Dapagliflozin Oral Product — DRUG
    Timing of drug intervention after PCI

Study Details

The objective of this trial is to examine the effect of immediate versus late administration of beta blockers, angiotensin converting enzyme inhibitors (ACEI), and sodium/glucose cotransporter 2 (SGLT2) inhibitors on echocardiographic parameters and biomarkers in subjects with ST-elevation myocardial infarction (STEMI)

Key Dates

Start date
Jan 6, 2025
Status verified
Aug 2024
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Bisoprolol
    Bisoprolol within 24 hours of PCI
  • No Intervention: No Bisoprolol
    no beta blocker until day 7±12 hours
  • Active Comparator: Ramipril
    Ramipril within 24 hours of PCI
  • No Intervention: No Ramipril
    no ramipril until day 7±12 hours after PCI
  • Active Comparator: Dapagliflozin
    Dapagliflozin within 24 hours versus
  • No Intervention: No Dapagliflozin
    no dapagliflozin treatment until day 7±12 hours after PCI

Primary Outcome Measure

Measurement of Global longitudinal strain (GLS, %) [ Time Frame: day 7±24 hours ]

Central Contacts

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