Mechanistic Underpinnings of Preeclampsia

Sponsor
University of Arizona
Study ID
NCT06567899
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

  • Preeclampsia

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

Preeclampsia is a dreadful disease with significant morbidity and mortality. Despite decades of research, we still need a proper diagnostic test or therapeutic option to treat this disorder. The proposed study will determine the diagnostic value of PBMC-secreted sFlt1 and determine the molecular mechanisms involved in its secretion. The molecular mechanisms can be novel therapeutic targets to treat this disorder.

Key Dates

First listed
Aug 23, 2024
Start date
Jul 25, 2026
Status verified
Oct 2025
Primary completion
Dec 31, 2027
Completion
Dec 31, 2029

Study Design

Enrollment
500 participants (estimated)

Arms

  • Arm: Non-pregnant with previous normal pregnancy
    Non pregnant females
  • Arm: Non-pregnant with previous known preeclampsia
    Women with known preeclampsia in previous pregnancy
  • Arm: First Trimester Pregnant (First antenatal visit)
    Women in first trimester
  • Arm: Second Trimester Pregnant
    Women in second trimester
  • Arm: Third Trimester with known preeclampsia
    Women in third trimester with diagnosis of preeclampsia
  • Arm: Third Trimester with Normal Pregnancy
    Women in third trimester with no complications.

Primary Outcome Measure

sFLT1 levels [ Time Frame: Outcome will be measured at 12 weeks, 24 weeks and 36 weeks of pregnancy. ]

Central Contacts

Related Studies