Thyroid Hormone Replacement After Radio Iodine: Value and Efficacy

Sponsor
University Medical Center Groningen
Study ID
NCT06647602
Status
Not Yet Recruiting

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Conditions

  • Differentiated Thyroid Cancer
  • Levothyroxine
  • Liothyronine
  • Thyroid Cancer
  • Thyroid Hormones

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Euthyrox (levothyroxine) — DRUG
    Euthyrox (levothyroxine sodium tablets; L-T4) is a thyromimetic synthetic drug identical to T4. Patients will recieve levothyroxine (euthyrox) in a dose of 2 μg × kg body weight / day.
  • Cytomel (liothyronine) — DRUG
    Cytomel (liothyronine sodium tablets; L-T3) is a thyromimetic synthetic drug identical to T3. The patients in this cohort recieve L-T4+L-T3 combination therapy. The L-T4 dose will be 2 μg × kg body weight / day, equal to the dose in the other interventional arm. L-T3 will be added twice daily from the first day of combination treatment, in dosages gradually decreasing from 25 ug 2/day to 5 ug 2/day over a time span of 3 weeks after which L-T3 is stopped.

Study Details

This study will be a multicentre prospective cohort study on TH-substitution after thyroid hormone withdrawal preceding radioiodine treatment.

Key Dates

First listed
Oct 18, 2024
Start date
Sep 1, 2026
Status verified
Feb 2026
Primary completion
Mar 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
40 participants (estimated)

Arms

  • Arm: TH-combination cohort
    L-T4+L-T3 combination according to local protocol.
  • Arm: Levothyroxine cohort
    L-T4 monotherapy according to local protocol.

Primary Outcome Measure

TSH after two weeks of TH substitution [ Time Frame: Before and after 2 weeks of TH-substitution ]

Central Contacts

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