Sedation and Guided Education for Depression Study

Sponsor
Stanford University
Study ID
NCT06705270
Status
Not Yet Recruiting

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Conditions

  • Major Depressive Disorder (MDD)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Response-focused education — BEHAVIORAL
    Once participants recover from sedation, they will receive education that is focused on their response to treatment.
  • Diagnosis-focused education — BEHAVIORAL
    Once participants recover from sedation, they will be provided education that is focused on their diagnosis of major depressive disorder.

Study Details

The goal of this clinical trial is to understand how patient education surrounding a one-time, consciousness-altering medical intervention impacts the antidepressant response to the intervention in adults with major depressive disorder. In this study, the consciousness-altering medical intervention is a single infusion of propofol, an intravenous anesthetic which might have antidepressant properties. The main question this study aims to answer is: Does the focus of patient education influence the antidepressant response to a single intravenous infusion of propofol? Researchers will compare response-focused vs. diagnosis-focused education. Qualifying participants will: * Undergo a single intravenous infusion of propofol which will induce a temporary state of sedation * Wear an EEG cap that records brain activity during sedation * Be randomized to receive either response-focused or diagnosis-focused education about their brain signals after they recover from sedation * Be asked to fill out surveys about their mood and other measures of well-being before and after treatment

Key Dates

First listed
Nov 26, 2024
Start date
Sep 30, 2026
Status verified
Apr 2026
Primary completion
Sep 30, 2028
Completion
Oct 31, 2028

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Response-focused education
    Patient education that is focused on treatment response
  • Active Comparator: Diagnosis-focused education
    Patient education that is focused on the diagnosis of major depressive disorder

Primary Outcome Measure

Depression severity [ Time Frame: From enrollment to 28 days after treatment ]

Central Contacts

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