Clinical Study on Thymus-Kidney Transplantation From Neonatal Donors for the Induction of Immune Tolerance

Sponsor
RenJi Hospital
Study ID
NCT06715865
Status
Not Yet Recruiting

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Conditions

  • Kidney Transplant

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Thymus Transplantation — PROCEDURE
    Thymus Transplantation

Study Details

Thymus transplantation for the induction of immune tolerance in kidney transplantation: This study aims to understand how thymus transplantation can induce immune tolerance in recipients of allogeneic kidney transplants to achieve the discontinuation of immunosuppressive therapy. It will evaluate the safety of thymus transplantation, explore the functional output of thymus tissue, investigate the optimal timing for withdrawal of immunosuppressants, and identify key indicators for the reconstruction of immune suppression capacity.

Key Dates

First listed
Dec 4, 2024
Start date
Jan 31, 2025
Status verified
Nov 2024
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Thymus Transplantation Group

Primary Outcome Measure

Duration of immunosuppressive therapy after surgery [ Time Frame: 2 years ]

Central Contacts

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