Description of the Immune Response to Yellow Fever Vaccination

Sponsor
Institut Pasteur
Study ID
NCT06718127
Status
Recruiting
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Conditions

  • Immunization
  • Infections

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • blood samples collection — BIOLOGICAL
    blood samples collected at D0 ,W1, W5, M3 and M6

Study Details

Vaccine protection depends on a specific adaptive immune memory. However, a little-explored aspect of certain live vaccines may provide beneficial, non-specific protection against infections or pathogens other than the one from which the vaccine is derived. This is the concept of innate immune memory or " trained immunity", which differs from adaptive memory in its non-specificity. Innate immune memory is triggered by exposure to immunostimulants, and offers protection against unrelated pathogenic threats for several months or even years. The project aims to carry out an exploratory study to observe, in the context of current practice, the immune response obtained after a subunit and a live attenuated vaccine

Key Dates

First listed
Dec 5, 2024
Start date
Sep 30, 2024
Status verified
Jun 2025
Primary completion
Apr 30, 2026
Completion
Apr 30, 2027

Study Design

Enrollment
38 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Other: People with an indication for primary immunization against yellow fever and typhoid
    People with an indication for primary immunization against yellow fever and typhoid and whose vaccination schedule includes two appointments 7 days apart

Primary Outcome Measure

Immunological profile of PBMCs, before and after yellow fever vaccination [ Time Frame: 6 months ]

Central Contacts

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