Measurable Residual Disease Detection Using Tumor-Informed ctDNA Surveillance After Curative-Intent Treatment in HPV-Independent Squamous Cell Carcinoma of the Head and Neck

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts Eye and Ear Infirmary
Study ID
NCT06744296
Status
Recruiting
Apply to this trial

Conditions

  • Squamous Cell Carcinoma of Head and Neck

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Blood Draws and Tissue Sample(s) — OTHER
    All participants on the study, regardless of arm, will be getting blood draws, and tissue samples.

Study Details

This study will test the ability of a personalized blood test to determine which head and neck cancer patients will have a recurrence after treatment.

Key Dates

First listed
Dec 20, 2024
Start date
Feb 3, 2025
Status verified
May 2025
Primary completion
Jan 6, 2027
Completion
Jan 6, 2029

Study Design

Enrollment
75 participants (estimated)

Arms

  • Arm: Patients Receiving only Surgery
    Patients in this group will only be those who receive surgery, and does not receive radiographic testing or chemotherapy.
  • Arm: Patients receiving chemoradiotherapy
    * Newly diagnosed AJCC 8th edition Stage III-IVB mucosal SCC of the head and neck, which includes tumors arising from the oral cavity, nasal cavity, paranasal sinuses, nasopharynx, oropharynx, hypopharynx, and larynx. * Available tissue for tumor-informed ctDNA panel creation. * Definitive treatment with standard of care surgery (arm 1) or chemoradiotherapy (arm 2)

Primary Outcome Measure

2 Years - Disease Free Survival (DFS) [ Time Frame: 2 weeks after treatment completion ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts Eye and EarBostonMassachusetts02114
Michael Cheung, MSc, CCRP
[email protected]
617-573-6060
Gjystina Lumaj
[email protected]
Daniel Faden, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Boston, MA

By research site
Massachusetts Eye and Ear· Boston, MA

Related Studies