Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain Axis

Sponsor
Shanghai Mental Health Center
Study ID
NCT06754319
Status
Enrolling By Invitation

Conditions

  • Obsessive-Compulsive Disorder
  • Tic Disorder

Eligibility Criteria

Sex
ALL
Age
7 Years - 17 Years
Healthy Volunteers
Accepted

Study Details

This study aims to investigate the characteristics of the microbiota-gut-brain axis in pediatric patients with obsessive-compulsive disorder (OCD) through performing an integrated analysis of gut microbiota, serum metabolomics, neuroimaging and electroencephalography (EEG), conducted before and after treatment with selective serotonin reuptake inhibitors (SSRIs). The results will be compared with those of pediatric OCD paitents comorbid with tic disorder (TD) and healthy controls. The findings are expected to further elucidate the potential pathogenesis of OCD, providing a theoretical basis for identifying novel clinical intervention targets and optimizing treatment strategies.

Key Dates

First listed
Dec 31, 2024
Start date
Aug 24, 2024
Status verified
Nov 2024
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
125 participants (estimated)

Arms

  • Arm: pediatric OCD patients
    Drug-naïve or drug-free pediatric patients with OCD will be enrolled in this group. After data collection, they will receive treatment with SSRIs.
  • Arm: pediatric OCD patients comorbid with TD
    Drug-naïve or drug-free pediatric OCD patients comorbid with TD will be enrolled in this group. After data collection, they will receive treatment with SSRIs and antipsychotics.
  • Arm: healthy controls
    Healthy children and adolescents will be enrolled in this group for data collection.

Primary Outcome Measure

Changes in the diversity and composition of the microbiome before and after drug treatment. [ Time Frame: Before and after treatment with SSRIs for 12 weeks ]

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