Psilocybin-Assisted Therapy for Physician Well-Being and Burnout

Part of paid clinical trials in San Diego, California.

Sponsor
University of California, San Diego
Study ID
NCT06814522
Phase
PHASE1/PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Burnout
  • Burnout, Healthcare Workers

Eligibility Criteria

Sex
ALL
Age
21 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Psilocybin, [3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate — DRUG
    25 mg, single dose of psilocybin
  • Real-time Biofeedback — DEVICE
    Real-time visual biofeedback signal derived from multimodal dyadic synchrony measures (e.g., EEG, autonomic physiology, facial expression, speech) presented to the therapist during therapy sessions to inform delivery of psychotherapy.

Study Details

Through an open-label study involving a small group of UCSD physicians experiencing burnout, the investigators will evaluate the feasibility, safety, and preliminary effectiveness of PAT to reduce burnout symptoms.

Key Dates

First listed
Feb 7, 2025
Start date
Jan 13, 2025
Status verified
Nov 2025
Primary completion
Jun 30, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Psilocybin-Assisted Therapy with Biofeedback
    Subjects will receive a single dose of psilocybin in conjunction with psychedelic-assisted therapy and real-time visual biofeedback available to the therapist during sessions.
  • Active Comparator: Psilocybin-Assisted Therapy without Biofeedback
    Subjects will receive a single dose of psilocybin in conjunction with psychedelic-assisted therapy, without real-time visual biofeedback available to the therapist during sessions.

Primary Outcome Measure

Stanford Professional Fulfillment Index (PFI) [ Time Frame: From enrollment until end of study at 12 week follow-up. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UC San DiegoSan DiegoCalifornia92037
Vy Nguyen
[email protected]
619-363-2465
Cory R Weissman, MD, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in San Diego, CA

By research site
UC San Diego· San Diego, CA

Related Studies