Sleep TMS for Depression

Part of paid clinical trials in Stanford, California.

Sponsor
Stanford University
Study ID
NCT06824415
Status
Recruiting
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Conditions

  • Major Depression
  • Sleep

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • TMS — DEVICE
    Transcranial magnetic stimulation (TMS) applies magnetic pulses to stimulate nerve cells in the brain.

Study Details

The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.

Key Dates

First listed
Feb 13, 2025
Start date
May 1, 2025
Status verified
Jun 2026
Primary completion
May 30, 2028
Completion
May 30, 2028

Study Design

Enrollment
55 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Active TMS, Sham TMS
    Participants will receive 2 sessions of Transcranial Magnetic Stimulation (TMS) delivered using standard intermittent theta-burst (iTBS) parameters (600 pulses, 3 min, 120% rMT). Participants will receive, on separate sessions, either active or sham iTBS delivered during wakefulness and/or NREM sleep stages while recording with Electroencephalography (EEG). Participants will perform the N-back task and Multi-source Interference Task (MSIT) during each session to measure working memory and cognitive control performance.
  • Experimental: Sham TMS, Active TMS
    Participants will receive 2 sessions of Transcranial Magnetic Stimulation (TMS) delivered during using standard intermittent theta-burst (iTBS) parameters (600 pulses, 3 min, 120% rMT). Participants will receive, on separate sessions, either active or sham iTBS delivered during wakefulness and/or NREM sleep stages while recording with Electroencephalography (EEG). Participants will perform the N-back task and Multi-source Interference Task (MSIT) during each session to measure working memory and cognitive control performance.

Primary Outcome Measure

Change in Baseline TMS-EEG after iTBS [ Time Frame: Baseline, end of iTBS (3 minutes) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Stanford UniversityStanfordCalifornia94305
Hansong Lee, MS
[email protected]
408-909-2203

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