4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
4D Molecular Therapeutics
Study ID
NCT06864988
Phase
PHASE3
Status
Active Not Recruiting

Conditions

  • Macular Neovascularization Secondary to Age-Related Macular Degeneration

Eligibility Criteria

Sex
ALL
Age
50 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • 4D-150 IVT (3E10 vg/eye) — BIOLOGICAL
    If randomized to the 4D-150 treatment arm, 4D-150 will be administered at the assigned dose level as a single dose IVT injection on Day 1
  • EYLEA® (aflibercept) Injection 2 mg (0.05mL) — BIOLOGICAL
    Eylea (aflibercept) will be administered at applicable visits

Study Details

A Phase 3, Randomized, Double-Masked, Active-Controlled Trial in Adults with Macular Neovascularization Secondary to Age-Related Macular Degeneration

Key Dates

Start date
Mar 3, 2025
Status verified
May 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2028

Study Design

Enrollment
480 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: 4D-150 IVT (3E10 vg/eye)
  • Active Comparator: Aflibercept (AFLB) 2 mg IVT

Primary Outcome Measure

Mean change from baseline in BCVA ETDRS letter score at Week 52 [ Time Frame: 52 Weeks ]

Locations (91)

FacilityCityStateZIP
Barnet Dulaney Perkins Eye CenterPhoenixArizona85016
Retinal Research Institute, LLCScottsdaleArizona85254
Retina Partners of Northwest ArkansasSpringdaleArkansas72764
California Retina ConsultantsBakersfieldCalifornia93309
Retina Vitreous Associates Medical GroupBeverly HillsCalifornia90211
The Retina PartnersEncinoCalifornia91436
Retina Associates of Southern CaliforniaHuntington BeachCalifornia92647
Northern California Retina Vitreous AssociatesMountain ViewCalifornia94040
Retina Consultants of San DiegoPowayCalifornia92064
Kaiser Permanente-Riverside Medical CenterRiversideCalifornia92505
Retinal Consultants Medical Group IncSacramentoCalifornia95825
Retinal Consultants Medical Group IncSacramentoCalifornia95840
Orange County Retina Medical GroupSanta AnaCalifornia92705
California Retina Consultants - Santa BarbaraSanta BarbaraCalifornia93103
Bay Area Retina AssociatesWalnut CreekCalifornia94598
University of Colorado, DenverAuroraColorado80045
Retina Consultants of Southern ColoradoColorado SpringsColorado80909
RSC Research, LLCDenverColorado80210
Connecticut Eye ConsultantsDanburyConnecticut06810
Retina Group of FloridaFort LauderdaleFlorida33308
Vitreo Retinal AssociatesGainesvilleFlorida34481
Florida Retina Institute - JacksonvilleJacksonvilleFlorida32216
Florida Retina ConsultantsLakelandFlorida33805
Florida Retina InstituteOrlandoFlorida32806
Retina Specialty InstitutePensacolaFlorida32503
Retina Associates of SarasotaSarasotaFlorida34232
Retina Vitreous Associates of FloridaSt. PetersburgFlorida33711
East Florida Eye InstituteStuartFlorida34994
Southeast Retina CenterAugustaGeorgia30909
Georgia Retina PCMariettaGeorgia30060
Retina Consultants of Hawaii‘AieaHawaii96701
University of ChicagoChicagoIllinois60637
Retina Associates - ElmhurstElmhurstIllinois60126
University Retina and Macula Associates, PCLemontIllinois60439
Illinois Retina AssociatesOak ParkIllinois60304
Springfield ClinicSpringfieldIllinois62703
Midwest Eye InstituteCarmelIndiana46290
Retina Associates of KentuckyLexingtonKentucky40509
Haik Humble Eye CenterWest MonroeLouisiana71291
Maine Eye CenterPortlandMaine04101
Retina Group of Washington, Chevy ChaseChevy ChaseMaryland20815
Cumberland Valley Retina Consultants PCHagerstownMaryland21740
Mid Atlantic Retina Specialists - HagerstownHagerstownMaryland21740
MD Medical ResearchWaldorfMaryland20745
New England Retina ConsultantsSpringfieldMassachusetts01107
Mississippi Retina AssociatesMadisonMississippi39110
Deep Blue Retina Clinical ResearchSouthavenMississippi38671
The Retina InstituteSt LouisMissouri63128
Sierra Eye AssociatesRenoNevada89502
Envision Ocular, LLCBloomfieldNew Jersey07003
NJ RetinaEdisonNew Jersey08820
NJ RetinaTeaneckNew Jersey07666
Eye Associates of New Mexico Vision Research CenterAlbuquerqueNew Mexico87109
Retina-Vitreous Surgeons of Central New YorkLiverpoolNew York13088
Vitreous Retina Macula Consultants of New YorkNew YorkNew York10022
Retina Associates of Western New YorkRochesterNew York14620
Western Carolina Retinal Associate PAAshevilleNorth Carolina28803
Duke Eye CenterDurhamNorth Carolina27705
North Carolina (NC) Retina AssociatesWake ForestNorth Carolina27587
Piedmont Retina Specialists - Winston Salem OfficeWinston-SalemNorth Carolina27157
Cole Eye InstituteClevelandOhio44195
Retina Associates of ClevelandClevelandOhio44122
Retina Associates of ClevelandClevelandOhio44130
Retina Vitreous CenterEdmondOklahoma73013
Verum Research, LLCEugeneOregon97401
EyeHealth Northwest PeterkortPortlandOregon97225
Mid Atlantic RetinaBethlehemPennsylvania18017
Erie Retina ResearchEriePennsylvania16507
The Scheie Eye InstitutePhiladelphiaPennsylvania19104
Charleston Neuroscience CenterCharlestonSouth Carolina29414
Charleston Neuroscience InstituteLadsonSouth Carolina29456
Palmetto Retina CenterWest ColumbiaSouth Carolina29169
Black Hills Regional Eye InstituteRapid CitySouth Dakota57701
Southeastern Retina AssociatesKnoxvilleTennessee37763
Retina Research Institute of TexasAbileneTexas79606
Texas Retina AssociatesArlingtonTexas76012
Austin Clinical ResearchAustinTexas78750
Austin Research Center for RetinaAustinTexas78705
Austin Retina AssociatesAustinTexas78705
Retina & Vitreous of Texas, PLLCBellaireTexas77401
Retina Consultants of HoustonBellaireTexas77401
Texas Retina CenterHoustonTexas77043
RCTX - Westover Hills Retina CenterSan AntonioTexas78251
Retina Associates of South Texas PASan AntonioTexas78240
Retina Consultants of Texas San AntonioSan AntonioTexas78240
Retina Consultants of TexasThe WoodlandsTexas77384
Strategic Clinical Research Group, LLCWillow ParkTexas76087
Retina Group of Washington, FairfaxFairfaxVirginia22031
Piedmont Eye CenterLynchburgVirginia24502
Retina Institute of VirginiaRichmondVirginia23235
Eye Clinic of WisconsinWausauWisconsin54403

Find similar trials in Phoenix, AZ

By research site
Barnet Dulaney Perkins Eye Center· Phoenix, AZRetinal Research Institute, LLC· Scottsdale, AZRetina Partners of Northwest Arkansas· Springdale, ARCalifornia Retina Consultants· Bakersfield, CARetina Vitreous Associates Medical Group· Beverly Hills, CAThe Retina Partners· Encino, CA