Research of Predictive Factors of in Vitro Fertilization (IVF) Outcome AI-IVF Study

Sponsor
Fondazione IRCCS Policlinico San Matteo di Pavia
Study ID
NCT06872294
Status
Recruiting
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Conditions

  • Autoimmune Diseases

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 43 Years
Healthy Volunteers
Not accepted

Study Details

Infertility is the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected intercourse, while subfertility means a delay in achieving pregnancy. Several factors can contribute to these conditions, such as autoimmune diseases like systemic thyroid and celiac diseases, rheumatoid arthritis, systemic lupus erythematosus, and endometriosis. Some of them may overlap, sharing a common immunological milieu. In this scenario, medically ART can help women carry on pregnancies if they are in stable disease remission and receive adequate treatment. However, the number of oocytes that can be ovulated under stimulation is highly variable, so the outcome of any IVF is linked to many factors, not only biological but also connected to the mean success rate of the fertility center. For these reasons, the need to find methods for identifying the best gametes and embryos to guarantee a successful pregnancy is becoming pressing. AI can be essential to develop prediction models for pregnancy outcomes for patients undergoing ART treatments. AI currently represents a modern way to obtain algorithms from a set of observable data that could help clinical decisions

Key Dates

First listed
Mar 12, 2025
Start date
Nov 22, 2024
Status verified
Mar 2025
Primary completion
Dec 31, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: patients with a positive autoimmune panel
    Women undergoing ART procedures with a positive autoimmune panel
  • Arm: patients with a negative autoimmune panel
    Women undergoing ART procedures with a negative autoimmune panel

Primary Outcome Measure

Predictive algorithm creation [ Time Frame: through study completion, an average of 2 years ]

Central Contacts

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