Neuromodulation and fMRI in Neurodegenerative Diseases Study

Sponsor
Sunnybrook Health Sciences Centre
Study ID
NCT06873750
Status
Not Yet Recruiting

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Conditions

  • Mild Cognitive Impairment
  • Neurodegeneration
  • Traumatic Brain Injury

Eligibility Criteria

Sex
ALL
Age
25 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Transcranial Alternating Current Stimulation — DEVICE
    Application of low amplitude alternating electric current across the participant's scalp.

Study Details

In addition to neuronal loss, dysfunction in brain network connectivity has been identified as a correlate of cognitive deficits in neurodegenerative and post-traumatic brain injury states. Transcranial alternating current stimulation (tACS) has been suggested as a promising, non-invasive, method of normalizing network connectivity and hence improving cognition, notably memory. This study will examine the efficacy of tACS at improving working memory performance in patients with neurodegeneration and its correlation to changes in network connectivity, based on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) imaging data.

Key Dates

First listed
Mar 13, 2025
Start date
Jun 1, 2026
Status verified
Apr 2026
Primary completion
Sep 1, 2028
Completion
Dec 1, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment
    All participants will receive transcranial alternating current stimulation.

Primary Outcome Measure

Assessment of cognitive benefits post tACS intervention [ Time Frame: 2 years ]

Central Contacts

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