Telomeres Length in Israeli Fibrotic ILD Patients

Sponsor
Barzilai Medical Center
Study ID
NCT06885515
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • leukocyte telomere length (LTL) will be measured using the Telomere Restriction Fragment (TRF) Analysis method — DIAGNOSTIC_TEST
    Peripheral blood leukocytes telomere length will be measured both by TRF analysis and by Nanopore sequencing. Both analyses will be conducted at the laboratory of Prof. Yehuda Tzfati at the Hebrew University, which is highly experienced in the field of telomere biology and in telomere length analysis. Blood samples will be taken once from each participant. No genetic sequencing will be performed as part of this study.

Study Details

Individuals with fibrotic interstitial lung diseases (FILD) will be recruited after providing informed consent. in addition to routine data as usually collected in the clinic, blood samples will be taken for measurement of telomeres length in peripheral blood leukocytes using both the Telomere Restriction Fragment (TRF) Analysis method and Nanopore sequencing. Participants with FILD will be followed-up for 2-year after recruitment, including clinical and pulmonary function tests at-least every 6 months, or more frequently, according to the treating physician discretion.

Key Dates

Start date
Feb 28, 2026
Status verified
Feb 2026
Primary completion
Dec 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: familial pulmonary fibrosis
    Patients with familial pulmonary fibrosis are those with at-least one first-degree or second-degree relative with FILD
  • Arm: non familial pulmonary fibrosis
    Patients with pulmonary fibrosis without relatives with FILD
  • Arm: control
    10 healthy age-matched controls with no personal or family history of lung disease will be recruited as well

Primary Outcome Measure

the prevalence of short LTL among Israeli patients with familial and sporadic FILD. [ Time Frame: 1 year ]

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