Urine Incontinence Occurrence and Sexual Hormones in Women With Chronic Spinal Cord Injury/Disease - a Pilot Study

Sponsor
Swiss Paraplegic Research, Nottwil
Study ID
NCT06892080
Status
Recruiting
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Conditions

  • Menstrual Cycle
  • Spinal Cord Injury
  • Urinary Incontinence

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

There is a knowledge gap about the influence of the menstrual cycle on bladder function in women with spinal cord injury. So far, studies regarding urinary incontinence have primarily focused on women after menopause. It has become clear that a lack of the sex hormone estrogen, which occurs after menopause, can lead to urinary incontinence. During the course of the menstrual cycle, women also experience fluctuations in their sex hormones, particularly estrogen. The estrogen level is highest before ovulation and decreases afterwards. The investigators aim to explore whether this drop in hormone levels could lead to more frequent urinary incontinence during this phase. In order to offer the patients optimal treatment for urinary incontinence, it is important to understand the potential causes behind it. Participants will document their menstrual cycles and episodes of urinary incontinences over three menstrual cycles using a diary, and urine tests. This research project is a pilot study and is being conducted by Swiss Paraplegic Research at the Swiss Paraplegic Centre. The investigators are recruiting 12 participants who experience incontinence at least once a month and 12 participants who experience incontinence less frequently or not at all.

Key Dates

First listed
Mar 24, 2025
Start date
Jul 1, 2025
Status verified
Jul 2025
Primary completion
Mar 1, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
24 participants (estimated)

Arms

  • Arm: Premenopausal women with spinal cord injury and urinary incontinence
  • Arm: Premenopausal women with spinal cord injury without urinary incontinence

Primary Outcome Measure

Incontinence event(s) [ Time Frame: through study completion, an average of 3 months ]

Central Contacts

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