Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study

Sponsor
Centre Hospitalier Universitaire de Besancon
Study ID
NCT06948565
Status
Recruiting
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Conditions

  • Acute on Chronic Liver Failure(ACLF)
  • Cirrhosis
  • Intensive Care Medicine

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • observational study — OTHER
    This observational study aims to describe the clinical practices and the outcome of patients admitted in ICU.

Study Details

Ten years after our team's publication, practices have changed considerably in the management of severe cirrhotic patients. This study will analyse these practices in primary care hospitals and in a tertiary centre, and assess the impact of these changes on the prognosis of these patients. The following hypotheses will be tested: * Improvement in intensive care and overall prognosis compared with data from the literature prior to 2014 * Improved access to liver transplantation compared with the literature prior to 2014 * Improvement in intensive care unit practices (for example: application of recommendations published by learned societies concerning the intensive care unit management of patients with cirrhosis, access to comfort care, degree of clinical severity on admission to the intensive care unit, etc.). * Centre' effect: variability in the phenotype of patients admitted to intensive care depending on the technical facilities available and whether or not the hospital centre has access to TH.

Key Dates

First listed
Apr 29, 2025
Start date
Aug 8, 2025
Status verified
Nov 2024
Primary completion
Dec 31, 2025
Completion
Dec 31, 2026

Study Design

Enrollment
500 participants (estimated)

Primary Outcome Measure

28-day survival [ Time Frame: 28 days ]

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