Association of Urinary Tract Infection With Preeclampsia During Pregnancy

Sponsor
Pakistan Air Force (PAF) Hospital Islamabad
Study ID
NCT06962644
Status
Recruiting
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Conditions

  • Preeclampsia
  • Urinary Tract Infection (Diagnosis)

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Preeclampsia developed — OTHER
    Preecalmpsia will be defined as per study protocol

Study Details

Urinary tract infections (UTIs) are a major clinical issue, especially in pregnant women, due to physiological changes that increase susceptibility. If untreated, UTIs can lead to severe complications like preterm labor and low birth weight. Preeclampsia, a hypertensive disorder affecting 0.2-9.2% of pregnancies, is another leading cause of maternal and fetal complications. The relationship between UTIs and preeclampsia remains controversial, with some studies suggesting an association while others show conflicting results. Research gaps highlight the need for region-specific studies, particularly in Pakistan, where both conditions contribute significantly to maternal and neonatal morbidity. This study aims to investigate the association between UTIs and preeclampsia in pregnant women in Pakistan. It will use a cohort design, enrolling 160 patients (80 with UTIs, 80 without) from the Obstetrics Department of PAF Hospital, Islamabad. Participants will be followed until delivery, with preeclampsia diagnosed based on blood pressure and proteinuria criteria. Data will be analyzed using SPSS to calculate relative risk (RR), with statistical significance set at RR \>1 and p ≤ 0.05. The findings could help improve prenatal care and reduce adverse outcomes in high-risk populations.

Key Dates

First listed
May 8, 2025
Start date
Jan 1, 2025
Status verified
Apr 2025
Primary completion
Apr 30, 2025
Completion
Apr 30, 2025

Study Design

Enrollment
160 participants (estimated)

Arms

  • Arm: UTI exposed
    Patients suffering from UTI as per protocol
  • Arm: UTI non exposed
    Patients having no clinical and laboratory evidence of UTI

Primary Outcome Measure

Preeclampsia [ Time Frame: 37 weeks of pregnancy ]

Central Contacts

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