Predicting Outcomes in Posttransplant Diabetes Mellitus Via microRNA

Sponsor
University Hospital, Martin
Study ID
NCT07055984
Status
Recruiting
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Conditions

  • Diabetes Mellitus
  • Kidney Transplant

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The study aims to improve the prediction and early detection of post-transplant diabetes mellitus (PTDM) in kidney transplant recipients. The investigators are investigating whether specific microRNA profiles measured 3 months after transplantation can reliably predict the development of PTDM within the following one to two years. Additionally, the investigators are evaluating how traditional risk factors-such as age, immunosuppressive therapy, obesity, and infections like CMV-interact with these microRNA markers. The ultimate goal of this research is to identify early indicators of blood sugar issues, enabling timely interventions to improve health outcomes and personalize patient care after kidney transplantation.

Key Dates

First listed
Jul 9, 2025
Start date
Apr 28, 2025
Status verified
Jun 2025
Primary completion
Apr 28, 2028
Completion
Apr 28, 2029

Study Design

Enrollment
130 participants (estimated)

Arms

  • Arm: patients after primary kidney transplantation without type 1 or type 2 diabetes melltus

Primary Outcome Measure

To identify a panel of microRNAs at 3 months post-kidney transplant that are significantly associated with the development of PTDM within a defined follow-up period (e.g., 1 year, 2 years). [ Time Frame: From enrollment to the end - 12 months ]

Central Contacts

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