Prevalence and Predictors of Incidental Thyroid Carcinoma in Patients With Graves' Disease Undergoing Thyroidectomy.

Sponsor
Minia University
Study ID
NCT07059507
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Total thyroidectomy — PROCEDURE
    Remove of both thyroid lobes and isthmus

Study Details

The prevalence of incidental thyroid cancer (ITC) in Graves' Disease (GD) patients undergoing thyroidectomy appears higher than historically believed, potentially exceeding 10% in large contemporary series, although significant variability exists. The presence of nodules is a strong predictor, while the roles of age, sex, and BMI require clarification. Most ITCs are papillary thyroid microcarcinoma(PTMCs) with generally favorable prognoses, but concerns about aggressiveness persist. The purpose of the present study is to accurately evaluate the prevalence of incidental thyroid carcinoma (ITC), including microcarcinomas, in a prospectively enrolled cohort of patients undergoing total thyroidectomy for Graves' disease, utilizing standardized pathological examination protocols and secondary outcomes including predictors and histopathological characteristics.

Key Dates

Start date
Jul 15, 2025
Status verified
Jul 2025
Primary completion
Jul 15, 2026
Completion
Aug 15, 2026

Study Design

Enrollment
280 participants (estimated)

Arms

  • Arm: Graves' Disease Undergoing Thyroidectomy
    Remove of both thyroid lobes and isthmus

Primary Outcome Measure

Prevalence of Incidental Thyroid Carcinoma (ITC) [ Time Frame: Assessed at the time of final pathology report post-surgery (within 30 days post-operation).Histopathological examination of thyroidectomy specimens using standardized protocols. ]

Central Contacts

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