Nutcracker: Can Almond Nut Consumption Improve Nocturnal Glycaemic Control in Women With Gestational Diabetes Mellitus?

Sponsor
Guy's and St Thomas' NHS Foundation Trust
Study ID
NCT07069855
Status
Not Yet Recruiting

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Conditions

  • Gestational Diabetes

Eligibility Criteria

Sex
FEMALE
Age
16 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • Almond Snack Intervention for Gestational Diabetes — OTHER
    This intervention involves daily consumption of 43 g of whole almonds, split into two portions (afternoon and evening), for 28 days in pregnant women diagnosed with gestational diabetes who habitually consume evening snacks.
  • Control (placebo) group — OTHER
    This control involves the daily consumption of a nut-free snack (2 portions) that reflects a 'typical snack' choice among pregnant women with gestational diabetes. It serves as a comparison to assess the specific impact of almond-based evening snacking on overnight glucose regulation.

Study Details

Gestational diabetes, affecting over one in six births globally, is a growing public health concern. Characterised by high blood glucose, it increases the risk of pregnancy complications and raises the mother's long-term risk of type 2 diabetes. Managing high fasting glucose, which reflects elevated overnight levels, is a key challenge. Night-time snacking-more common in women with gestational diabetes-is linked to higher fasting glucose, but the impact of snack quality is unclear. Almonds have been shown to improve glucose control in non-pregnant adults. This study will test whether almonds, as a night-time snack, can improve overnight glucose levels in pregnant women with gestational diabetes. Findings could support a simple, effective dietary strategy to improve outcomes for mothers and babies worldwide.

Key Dates

First listed
Jul 17, 2025
Start date
Jul 31, 2025
Status verified
Jul 2025
Primary completion
Oct 31, 2025
Completion
Oct 31, 2025

Study Design

Enrollment
156 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Almond group
    Participants in the almond group will consume 43 g of almonds daily for 28 days, divided into two equal portions: one in the afternoon and one in the evening.
  • Placebo Comparator: Control group
    Participants in the control group will consume nut-free snacks (e.g., crackers or savoury biscuits) that are energy-matched to the almond snacks.

Primary Outcome Measure

Mean nocturnal blood glucose (22.00-07.00h) [ Time Frame: The primary endpoint will be assessed on day 14 and day 28 of the intervention. ]

Central Contacts

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