The Effect of Sitagliptin, Pioglitazone and Dapagliflozine on Myocardial Infarction in Diabetic Rats

Sponsor
Al-Azhar University
Study ID
NCT07083232
Phase
PHASE4
Status
Completed

Conditions

  • Diabetic
  • Myocardial Infarction

Eligibility Criteria

Sex
MALE
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • standard normal diet — DIETARY_SUPPLEMENT
    Group I: formed of normal animals. They were allowed standard normal diet and water. They received no drugs
  • low dose Streptozotocin — DRUG
    Non-treated diabetic rats; diabetes was induced by administration of 20% fructose solution in drinking water for 2 weeks, then intra peritoneal injection of a low dose STZ (40 mg/kg b.w.), was done
  • Sitagliptin (Novartis, USA) — DRUG
    Sitagliptin treated diabetic group sitagliptin was administered by gastric gavage in a dose 10mg/ kg /day for 4 weeks
  • Pioglitazone hydrochloride (Unipharma., Egypt) — DRUG
    Pioglitazone treated diabetic group (G4); Pioglitazone was administered by gastric gavage in a dose 10 mg/ kg /day for 4 weeks
  • Dapagliflozine hemihydrate (Janssen, USA) — DRUG
    Dapagliflozine treated diabetic group (G5); Dapagliflozine was administered by gastric gavage in a dose 1mg/ kg /day for 4 weeks

Study Details

The aim of the present study is to evaluate the prophylactic effect of Sitagliptin, Pioglitazone and Dapagliflozine on Isoprenaline induced myocardial infarction in type II diabetic rats.

Key Dates

Start date
Oct 30, 2024
Status verified
Jul 2023
Primary completion
Oct 30, 2024
Completion
Nov 30, 2024

Study Design

Enrollment
50 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Placebo Comparator: standard normal diet and water group
    Group I: formed of normal animals. They were allowed standard normal diet and water. They received no drugs.
  • Experimental: low dose Streptozotocin group
    Group II: Non-treated diabetic rats; diabetes was induced by administration of 20% fructose solution in drinking water for 2 weeks, then intra peritoneal injection of a low dose STZ (40 mg/kg b.w.)
  • Experimental: Sitagliptin group
    Group III: Sitagliptin treated diabetic group sitagliptin was administered by gastric gavage in a dose 10mg/ kg /day for 4 weeks
  • Experimental: Pioglitazone group
    Group IV : Pioglitazone treated diabetic group ; Pioglitazone was administered by gastric gavage in a dose 10 mg/ kg /day for 4 weeks
  • Experimental: Dapagliflozine group
    Group V : Dapagliflozine treated diabetic group (G5); Dapagliflozine was administered by gastric gavage in a dose 1mg/ kg /day for 4 weeks

Primary Outcome Measure

blood glucose [ Time Frame: one week ]

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