Comparison of Two Different Regional Anesthetic Methods in Total Knee Arthroplasty Patients

Sponsor
SB Istanbul Education and Research Hospital
Study ID
NCT07092982
Status
Recruiting
Apply to this trial

Conditions

  • Adductor Canal Block
  • Total Knee Arthroplasty
  • Ultrasound Guided Supra-inguinal Fascia Iliaca Block

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Ultrasound Guided Suprainguinal Fascia Iliaca Block — PROCEDURE
    Ultrasound Guided Suprainguinal Fascia Iliaca Block, 30 ml Bupivacain %0,25
  • Ultrasound Guided Adductor Canal Block — PROCEDURE
    Ultrasound Guided Adductor Canal Block, 15ml Bupivacain %0,25
  • Ultrasound Guided iPACK Block — PROCEDURE
    Ultrasound Guided iPACK Block, 15ml Bupivacain %0,25

Study Details

Total Knee Arthroplasty patients are among the orthopedic cases that experience severe postoperative pain. In these cases, pain must be controlled. If pain is not controlled, early mobilization cannot be achieved. This can result in delayed physical therapy, prolonged hospital stays, the development of nosocomial infections, and impaired cognitive function. All of these factors contribute to increased patient care costs. Multimodal analgesia methods are used to control this pain. One of these methods is peripheral nerve blocks. Peripheral nerve blocks provide pain control and reduce the likelihood of opioid use and related side effects such as nausea, vomiting, and constipation. Current studies recommend Adductor Canal Blocks and iPACK (space between the popliteal artery and the posterior knee capsule) blocks for Total Knee Arthroplasty patients. In addition, studies are also being conducted on the application of the Suprainguinal Fascia-Iliaca Block in Total Knee Arthroplasty patients. The differences in postoperative analgesic effects between these methods are a matter of interest. No study has been conducted comparing the effects of these two approaches, which are routinely applied in our clinic and comply with guidelines, on the postoperative stress response. Regional anesthesia provides adequate pain control and has a positive effect on the stress response. The investigators aim to see a similar effect in peripheral nerve blocks. Therefore, comparing the methods that mentioned will contribute to the literature. In this study, the effects of these two different approaches on postoperative stress response and analgesic efficacy will be compared in terms of patients' postoperative opioid consumption, pain at rest and with movement, time to first analgesic need and development of motor block. IL-6 and CRP values will be examined pre-operatively and post-operatively to measure the effects on the stress response.

Key Dates

First listed
Jul 30, 2025
Start date
Aug 4, 2025
Status verified
Jul 2025
Primary completion
Jul 1, 2026
Completion
Jul 31, 2026

Study Design

Enrollment
52 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Ultrasound Guided Fascia Iliaca Block
    Suprainguinal fascia iliaca block was applied to the patients in this group at the end of the operation.
  • Active Comparator: Ultrasound Guided Adductor Canal Block + iPACK Block
    Adductor Canal Block and iPACK Block was applied to the patients in this group at the end of the operation.

Primary Outcome Measure

Cumulative opioid consumption [ Time Frame: 24 hours ]

Central Contacts

Related Studies