Hematological Disorders in EHPVO Patients

Sponsor
Rahab Nady
Study ID
NCT07108023
Status
Not Yet Recruiting

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Conditions

  • Anemia
  • Antiphospholipid Syndrome (APS)
  • Extrahepatic Portal Vein Obstruction (EHPVO)
  • Leukopenia
  • Myeloproliferative Neoplasms (MPN)
  • Paroxysmal Nocturnal Hemoglobinuria (PNH)
  • Thrombocytopenia
  • Thrombophilia

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • No intervention (Observational Study) — OTHER
    This is a retrospective observational study with no assigned intervention. Data will be collected from patient medical records only

Study Details

This study focuses on patients who have a condition called extrahepatic portal vein obstruction (EHPVO), where a blood clot blocks the portal vein outside the liver. This blockage can cause problems like an enlarged spleen, bleeding from swollen veins in the digestive system, and low blood cell counts. Many of these patients may have hidden blood disorders that increase the risk of clotting, such as myeloproliferative neoplasms (MPNs), antiphospholipid syndrome (APS), or paroxysmal nocturnal hemoglobinuria (PNH). This study will collect and analyze blood test results-such as complete blood count (CBC), liver function tests (LFTs), and clotting tests-from patients with EHPVO. The aim is to find patterns that may suggest an underlying blood disorder, even if the patient doesn't show obvious symptoms.By understanding these patterns early, doctors may be able to diagnose and treat the root causes of clotting in these patients more accurately, helping prevent complications and improve outcomes.

Key Dates

Start date
Aug 31, 2025
Status verified
Jul 2025
Primary completion
Dec 31, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
115 participants (estimated)

Arms

  • Arm: EHPVO Patients
    Patients diagnosed with extrahepatic portal vein obstruction (EHPVO) based on imaging (Doppler ultrasound, CT, or MRI) and with preserved liver function. This group will be assessed for hematological abnormalities, including cytopenias and coagulation disturbances, using retrospective laboratory data.

Primary Outcome Measure

Frequency of hematological disorders in EHPVO patients [ Time Frame: Over a retrospective period from 2020 to 2024 ]

Central Contacts

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