Risk of Acute Kidney Injury in Pulmonary Endarterectomy

Sponsor
China-Japan Friendship Hospital
Study ID
NCT07135206
Status
Not Yet Recruiting

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Conditions

  • Acute Kidney Injury

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Study Details

This study aims to assess the perioperative risk factors for acute kidney injury (AKI) in patients undergoing pulmonary endarterectomy (PEA) with deep hypothermic circulatory arrest (DHCA). By analyzing retrospective data (2016-2025) from approximately 240 PEA patients and prospectively enrolling 44 patients (2025-2027), we will identify clinical risk factors, establish and validate a comprehensive prediction model, and explore the dynamic characteristics and predictive value of novel biomarkers (e.g., NGAL, KIM-1). The goal is to improve early warning and management of PEA-related AKI, thereby enhancing patient outcomes.

Key Dates

First listed
Aug 22, 2025
Start date
Jan 1, 2026
Status verified
Aug 2025
Primary completion
Dec 31, 2028
Completion
Jul 30, 2029

Study Design

Enrollment
284 participants (estimated)

Arms

  • Arm: PEA Patients with AKI Risk Assessment Cohort
    This cohort integrates retrospective and prospective data from patients undergoing pulmonary endarterectomy (PEA) with deep hypothermic circulatory arrest (DHCA) at China-Japan Friendship Hospital. It includes: 1) Retrospective cases (2016-2025, \~240 cases) to explore perioperative risk factors for PEA-related acute kidney injury (AKI); 2) Prospective cases (2025-2027, 44 cases) to validate prediction models and analyze dynamic biomarkers (e.g., NGAL, KIM-1). The cohort aims to comprehensively assess AKI risk through combined analysis of historical and real-time data.

Primary Outcome Measure

Occurrence of Acute Kidney Injury (AKI) after Pulmonary Endarterectomy (PEA) [ Time Frame: Within 7 days after PEA surgery ]

Central Contacts

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